Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (6): 999-1002.

• Articles • Previous Articles     Next Articles

One-pot Three-component Synthesis of 4,4′-Arylidene-bis(3-methyl-pyrazolones) Derivatives in Water

JIA Xu-dong, DUAN Hai-feng, LIN Ying-jie, CAO Jun-gang, LIANG Da-peng, WU Mao-cheng   

  1. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China
  • Received:2011-12-05 Revised:2012-01-13 Online:2012-11-25 Published:2012-11-09
  • Contact: DUAN Hai-feng, LIN Ying-jie E-mail:duanhf@jlu.edu.cn;linyj@jlu.edu.cn

Abstract:

Aldehydes, hydrazine and ethyl acetoacetate were used for the synthesis of 4,4′-arylidene-bis (3-methyl-pyrazolones) derivatives in water. In this green synthetic protocol, the solvent water itself catalyzed the reaction via hydrogen bonding, thus avoiding the use of any other catalyst to make the work up procedure easier. One-pot, environmental friendly and convenient are the highlights.

Key words: 4,4′-Arylidene-bis(3-methyl-pyrazolones), Catalysis, Multi-component reaction