Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (5): 886-890.

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Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR

WANG Wen-jun¹, CAO Chen-ming¹, JIN Chen¹, WANG Xin^1,2* and WANG George-peng^1,3

1. College of Pharmacy,
2. State Key Laboratory of Element-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China;
3. Departments of Chemistry and Biochemistry, The Ohio State University, Columbus OH 43210, USA

Received:2010-11-02 Revised:2011-03-29 Online:2011-09-25 Published:2011-09-06
Contact: WANG Xin E-mail:wangxinnk@nankai.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.2007CB914403, 50803029), the Natural Science Foun- dation of Tianjin City, China(No.10JCYBJC04100) and the Fundamental Research Funds for the Central Universities of China.

Abstract

Abstract: The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar redu- cing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.

Key words: Glycoconjugate, Aniline, Catalysis, Kinetics, Real-time NMR

WANG Wen-jun, CAO Chen-ming, JIN Chen, WANG Xin* and WANG George-peng. Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR[J]. Chemical Research in Chinese Universities, 2011, 27(5): 886-890.

References

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Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR

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