Preparation of 3,4-Dihydropyrimidones via Biginelli Reaction in Efficient and Recyclable PEG1000-DAIL/Toluene Catalyst-mediumCombined Thermoregulated Biphasic System

doi:10.1007/s40242-013-3087-6

Abstract

Abstract:

A facile and efficient protocol for the synthesis of 3,4-dihydropyrimidones via one-pot Biginelli reaction in PEG₁₀₀₀-DAIL/toluene system was developed. PEG₁₀₀₀-DAIL/toluene mixture is a temperature-driven reversible biphasic system, which promises the fully display of catalytic activity and simple recycle of PEG₁₀₀₀-DAIL. As a result, PEG₁₀₀₀-DAIL/toluene mixture showed catalyst-medium double-duty in the Biginelli reaction and afforded corresponding 3,4-dihydropyrimidones in excellent yields of 80%―95% for 20 examples. No obvious loss of catalytic activity was observed even after 10 recycling runs.

Key words: Thermoregulated biphase, Ionic liquid, Multicomponent reaction, Biginelli reaction, Green chemistry, Catalysis

WANG Ying-lei, LUO Jun, ZHI Hui-zhen. Preparation of 3,4-Dihydropyrimidones via Biginelli Reaction in Efficient and Recyclable PEG₁₀₀₀-DAIL/Toluene Catalyst-mediumCombined Thermoregulated Biphasic System[J]. Chemical Research in Chinese Universities, 2013, 29(5): 879-883.

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Preparation of 3,4-Dihydropyrimidones via Biginelli Reaction in Efficient and Recyclable PEG₁₀₀₀-DAIL/Toluene Catalyst-mediumCombined Thermoregulated Biphasic System

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