PEG-grafted PVA Membrane and Its Blood Compatibility

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (6): 1078-1082.

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PEG-grafted PVA Membrane and Its Blood Compatibility

JIN Gu*, YAO Qi-zhi, DONG Li-quan and MA Feng

Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China

Received:2011-01-07 Revised:2011-08-18 Online:2011-11-25 Published:2011-11-07
Contact: JIN Gu E-mail:gjin@ustc.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.29405038).

Abstract

Abstract: Preparation and blood compatibility of different shape polyvinyl alcohol(PVA) membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene(PTFE) capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol(mPEG) was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

Key words: Polyvinyl alcohol(PVA), Polyethylene glycol(PEG), Membrane, Platelet, Adhesion

JIN Gu*, YAO Qi-zhi, DONG Li-quan and MA Feng. PEG-grafted PVA Membrane and Its Blood Compatibility[J]. Chemical Research in Chinese Universities, 2011, 27(6): 1078-1082.

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PEG-grafted PVA Membrane and Its Blood Compatibility

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