Preparation of Poly(ε-caprolactone)/Poly(ester amide) Electrospun Membranes for Vascular Repair

doi:10.1007/s40242-022-1480-8

Abstract

Abstract: With adjustable amphiphilicity and anionic/cationic charge, biodegradability and biocompatibility, amino acid-based poly(ester amide)s(PEAs) have drawn attention in the research of tissue engineered vascular grafts. In this work, L-phenylalanine-based PEAs with or without L-lysine were synthesized through polycondensation, and ultrafine fibrous grafts consisted of PEAs and poly(ε-caprolactone)(PCL) in given mass ratios were further prepared via blend electrospinning. Surface characterizations by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the chemical structure, and the wettability indicated that the prepared PCL/PEAs electrospun membranes exhibited less hydrophobic than PCL. Tensile results showed that the PCL/PEAs membranes possessed suitable mechanical properties, which could meet the requirements of artificial blood vessels. Cell culture and hemolytic tests exhibited that the PCL/PEAs electrospun membranes are biocompatible. In general, the electrospun grafts of PCL/PEAs could be applied for vascular repair.

Key words: Poly(ester amide), Poly(ε-caprolactone), Electrospun membrane, Mechanical property, Vascular repair

ZHANG Xiangyu, BAI Shan, ZANG Leilei, CHEN Xiaoqi, YUAN Xiaoyan. Preparation of Poly(ε-caprolactone)/Poly(ester amide) Electrospun Membranes for Vascular Repair[J]. Chemical Research in Chinese Universities, 2022, 38(4): 1111-1117.

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