Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer

doi:10.1007/s40242-021-1068-8

Chemical Research in Chinese Universities ›› 2022, Vol. 38 ›› Issue (2): 562-571.doi: 10.1007/s40242-021-1068-8

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Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer

WU Liting, XIN Yujia, GUO Zhaoyang, GAO Wei, ZHU Yanpeng, WANG Yinsong, RAN Ruixue, YANG Xiaoying

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China

Received:2021-02-20 Revised:2021-04-12 Online:2022-04-01 Published:2021-05-08
Contact: RAN Ruixue, YANG Xiaoying E-mail:ranruixue@tmu.edu.cn;yangxiaoying@tmu.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China(No.12074284) and the Natural Science Foundation of Tianjin City, China(No.20JCYBJC00170).

Abstract

Abstract: Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT.

Key words: Dendritic large pore mesoporous silica nanoparticle, Photothermal therapy, Radiosensitization, Red blood cell membrane, Oxygen carrying

WU Liting, XIN Yujia, GUO Zhaoyang, GAO Wei, ZHU Yanpeng, br, WANG Yinsong, RAN Ruixue, YANG Xiaoying. Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer[J]. Chemical Research in Chinese Universities, 2022, 38(2): 562-571.

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Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer

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