A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube

doi:10.1007/s40242-021-1267-3

Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (5): 1085-1091.doi: 10.1007/s40242-021-1267-3

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A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube

SUN Di^1,2, GAO Wenqing^3,4, WU Peng^3,4, LIU Jie⁵, LI Shengmei², LI Shilin², YU Meili^3,4, NING Meng^3,4, BAI Ru², LI Tong^3,4, LIU Ying^1,2, CHEN Chunying^1,2

1. GBA Research Innovation Institute for Nanotechnology, Guangzhou 510700, P. R. China;
2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China;
3. Department of Cardiac Center, Tianjin Third Central Hospital, Tianjin 300170, P. R. China;
4. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, P. R. China;
5. Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing 100853, P. R. China

Received:2021-07-16 Revised:2021-08-16 Online:2021-10-01 Published:2021-08-23
Contact: LI Tong, LIU Ying, CHEN Chunying E-mail:litong3zx@sina.com;liuy@nanoctr.cn;chenchy@nanoctr.cn
Supported by:
This work was supported by the Key-Area Research and Development Program of Guangdong Province, China(Nos.2020B0101020001, 2019B090917011), the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB36000000), the Innovative Research Groups of the National Natural Science Foundation of China(No.11621505), the National Natural Science Foundation of China(No.31971318), the Key Fund of the Tianjin Health Commission, China(No.2014KR01), the Youth Fund of the Tianjin Science and Technology Commission, China(No.17JCQNJC10000), and the Tianjin "Project+Team" Key Training Special Project, China(No.XC202040).

Abstract

Abstract: Extracorporeal membrane oxygenation(ECMO) has emerged as a viable treatment in severe cases of acute respiratory distress syndrome, acute respiratory failure, and adult respiratory distress syndrome. However, thromboembolic events stemming from the use of ECMO devices results in significant morbidity and mortality rates; the inner surface of the ECMO tubing comes into contact with the blood and can readily initiate coagulation. In addition, the tubing needs to be continually replaced due to thromboses on the inner tube wall, which not only increases the risk of infection but also the economic burden. Despite considerable effort, a surface modification strategy that effectively addresses these challenges has not yet been realized. In this study, we developed an integrated hollow core-shell-shell hydrogel tube of gelatin/alginate/acrylamide-bacterial nanocellulose(GAA) that meets the anticoagulant requirements for the inner tubing layer as well as the highly elastic soft material needed for the outer layer. Using static blood from healthy volunteers, we confirmed that the platelets or coagulation is not stimulated by the GAA tubing. Importantly, experiments with dynamic blood also demonstrated that the inner layer of the tubing does not elicit blood clotting. The one-pot-synthesized process may provide guidance for the design of anticoagulation tubes used clinically.

Key words: Hydrogel, Extracorporeal membrane oxygenation(ECMO) tube, Coagulation, Core-shell-shell

SUN Di, GAO Wenqing, WU Peng, LIU Jie, LI Shengmei, LI Shilin, YU Meili, NING Meng, BAI Ru, LI Tong, LIU Ying, CHEN Chunying. A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube[J]. Chemical Research in Chinese Universities, 2021, 37(5): 1085-1091.

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A One-pot-synthesized Double-layered Anticoagulant Hydrogel Tube

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