A Facile Synthesis of 4-Alkyl-2-Quinolones

Chemical Research in Chinese Universities ›› 1992, Vol. 8 ›› Issue (1): 45-47.

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A Facile Synthesis of 4-Alkyl-2-Quinolones

Huang Xian, Ye Fangchen

Department of Chemistry, Hangzhou University, Hangzhou

Received:1990-11-07 Online:1992-01-24 Published:2011-09-09
Supported by:
Supported by the National Natural Science Foundation of China

Abstract

Abstract: The derivatives of 4-alkyl-2-quinolones possess a variety of biological activities. The general synthetic method of 4-alkyl-2-quinolones is the reaction of aryl amines with β-ketoesters to form β-ketoamides, which are then heated in concentrated sulfuric acid to complete the ring closure. Although a number of its 4-methyl and aryl derivatives have been obtained, other 4-alkyl-2-quinolones are rarely mentioned for lack of a convenient method to prepare the appropriate β-ketoesters used in condensation.

Key words: Quinolones, Meldrum' s acid, Acylation, Aminolysis, Synthesis

Huang Xian, Ye Fangchen . A Facile Synthesis of 4-Alkyl-2-Quinolones[J]. Chemical Research in Chinese Universities, 1992, 8(1): 45-47.

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A Facile Synthesis of 4-Alkyl-2-Quinolones

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