Rational Design of Ratiometric Fe3+ Fluorescent Probes Based on FRET Mechanism

doi:10.1007/s40242-021-1398-6

Chemical Research in Chinese Universities ›› 2022, Vol. 38 ›› Issue (1): 67-74.doi: 10.1007/s40242-021-1398-6

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Rational Design of Ratiometric Fe³⁺ Fluorescent Probes Based on FRET Mechanism

LI Mingfeng, FANG Hongbao, JI Yifan, CHEN Yuncong, HE Weijiang, GUO Zijian

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center(ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China

Received:2021-09-28 Revised:2021-10-18 Online:2022-02-01 Published:2021-11-08
Contact: FANG Hongbao, CHEN Yuncong, HE Weijiang, GUO Zijian E-mail:fangh2@nju.edu.cn;chenyc@nju.edu.cn;heweij69@nju.edu.cn;zguo@nju.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (Nos.21977044, 21731004, 21907050, 91953201, 22122701), the Natural Science Foundation of Jiangsu Province, China(Nos.BK20190282, BK20202004), the Excellent Research Program of Nanjing University, China(No.ZYJH004), the Fundamental Research Funds for the Central Universities, China (No.090314380036), the National Postdoctoral Program for Innovative Talents, China(No.BX2021123), the China Postdoctoral Science Foundation (No.2021M691505), and the Jiangsu Postdoctoral Research Funding Program, China(No.2021K125B).

Abstract

Abstract: As the most abundant transition metal element in mammals, iron(Fe) plays a vital role in life activities. It is of great significance to study the variation of Fe³⁺ level in living organisms. In virtue of the advantages of high sensitivity, good selectivity and low damage to living systems, the fluorescence detection of Fe³⁺ has attracted much attention. Compared with the intensity-based fluorescent probe, the ratiometric fluorescent probe has less interference of environmental and can realize quantitative detection. In this study, four ratiometric Fe³⁺ fluorescent probes, R1, R2, R3 and R4_, were designed and synthesized using fluorescence resonance energy transfer(FRET) mechanism to achieve quantitative detection of Fe³⁺. In the FRET systems, 1,8-naphthalimide fluorophore derivatives were adopted as donors while rhodamine B derivatives were selected as receptors. The connection sites of the donor and acceptor in R3 and R4 are different from those in R1 and R2. All the four probes showed good response and selectivity to Fe³⁺. The energy transfer efficiencies of R3 and R4 were obviously higher than those of R1 and R2. This work provided a promising strategy for the development of fluorescent ratiometic Fe³⁺sensors.

Key words: Fluorescent probe, Fluorescence resonance energy transfer(FRET), Fe³⁺, Ratiomertic detection

LI Mingfeng, FANG Hongbao, JI Yifan, CHEN Yuncong, HE Weijiang, GUO Zijian. Rational Design of Ratiometric Fe³⁺ Fluorescent Probes Based on FRET Mechanism[J]. Chemical Research in Chinese Universities, 2022, 38(1): 67-74.

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Rational Design of Ratiometric Fe³⁺ Fluorescent Probes Based on FRET Mechanism

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