A Novel Fluorescent Probe for ATP Detection Based on Synergetic Effect of Aggregation-induced Emission and Counterion Displacement

doi:10.1007/s40242-021-0400-7

Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (1): 166-170.doi: 10.1007/s40242-021-0400-7

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A Novel Fluorescent Probe for ATP Detection Based on Synergetic Effect of Aggregation-induced Emission and Counterion Displacement

PAN Quan¹, MA Feiyan¹, PU Xinqing¹, ZHAO Manyi¹, WU Qiling¹, ZHAO Na¹, YANG Jun¹, TANG Ben Zhong²

1. Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, P. R. China;
2. Department of Chemistry, The Hong Kong University of Science & Technology(HKUST), Clear Water Bay, Kowloon, Hong Kong, P. R. China

Received:2020-11-30 Revised:2020-12-24 Online:2021-02-01 Published:2020-12-28
Contact: ZHAO Na, YANG Jun, TANG Ben Zhong E-mail:nzhao@snnu.edu.cn;junyang@snnu.edu.cn;tangbenz@ust.hk
Supported by:
This work was supported by the National Natural Science Foundation of China(No.21975149), the Funded Projects for the Academic Leaders and Academic Backbones, Shaanxi Normal University, China(No.18QNGG007), and the Fundamental Research Funds for the Central Universities of China (No.GK202003036).

Abstract

Abstract: In this work, a fluorescent probe(TPEBe-I) was developed for adenosine triphosphate(ATP) detection based on the synergetic effect of aggregation-induced emission and counterion displacement. TPEBe-I gave weak emission in aqueous solution due to the heavy-atom effect of counter iodide ion. However, upon the addition of ATP, the new aggregate complex(TPEBe-ATP) was formed between the cationic unit of TPEBe-I and ATP through electrostatic interactions, which not only restricted the intramolecular motion of luminogen but also eliminated the quenching effect of iodide ion. As a result, the fluorescent light-up detection for ATP was successfully achieved. Moreover, TPEBe-I exhibited high selectivity towards ATP and showed a wide linear detection region towards the logarithm of ATP concentration(5-600 μmol/L) with a detection limit of 1.0 μmol/L, enabling TPEBe-I as a promising probe for ATP quantitative analysis.

Key words: Fluorescent probe, Adenosine triphosphate, Aggregation-induced emission, Counterion displacement

PAN Quan, MA Feiyan, PU Xinqing, ZHAO Manyi, WU Qiling, ZHAO Na, YANG Jun, TANG Ben Zhong. A Novel Fluorescent Probe for ATP Detection Based on Synergetic Effect of Aggregation-induced Emission and Counterion Displacement[J]. Chemical Research in Chinese Universities, 2021, 37(1): 166-170.

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A Novel Fluorescent Probe for ATP Detection Based on Synergetic Effect of Aggregation-induced Emission and Counterion Displacement

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