Syntheses and Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group

Abstract

Abstract: (E)-2-(1H-Benzo[d][1,2,3]triazol-1-yl)-3-(4-chlorophenyl)-3-hydroxy-N-phenylprop-2-enethioamide(compound 1) and (E)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-3-hydroxy-N,3-diphenylprop-2-enethioamide(compound 2) were synthesized and their structures were confirmed by means of IR, MS, ¹H NMR, and elemental analysis. The structure of compound 1 was determined with singlecrystal X-ray diffraction analysis. The results of the biological test show that the two compounds have a certain antifungal activity.

Key words: Benzotriazole, Thioamide, Crystal structure, Biological activities

XU Liang-zhong, ZHAI Zhi-wei, YU Guan-ping, QIN Yong-qi , YANG Ya-xun. Syntheses and Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group
[J]. Chemical Research in Chinese Universities, 2006, 22(5): 574-576.

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Syntheses and Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group

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