Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

Abstract

Abstract: Novel sandwich structure-like nano?ber multilayered meshes were fabricated via electrospinning. The purpose of the present work was to control zoledronic acid release via the novel structure of sandwich structure-like meshes. The in vitro release experiments reveal that the drug release speed and initial burst release were controllable by adjusting the thicknesses of electrospun barrier mesh and drug-loaded mesh. Compared with those of other drug delivery systems, the main advantages of the sandwich structure-like fiber meshes are facile preparation conditions and the generality for hydrophobic and hydrophilic pharmaceuticals.

Key words: Sandwich structured nanofiber mesh, Zoledronic acid, Drug release, Electrospinning

CLC Number:

Q819

LU Jian, LIU Jian-guo*, SONG Xiao-feng, CHEN Xue-si and WU Xiao-dong. Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid[J]. Chemical Research in Chinese Universities, 2011, 27(3): 524-527.

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Sandwich Structure-like Meshes Fabricated via Electrospinning for Controllable Release of Zoledronic Acid

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