One Step Fabrication and Application of Antibacterial Electrospun Zein/Cinnamon Oil Membrane Wound Dressing via In situ Electrospinning Process

doi:10.1007/s40242-021-1037-2

Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (3): 464-469.doi: 10.1007/s40242-021-1037-2

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One Step Fabrication and Application of Antibacterial Electrospun Zein/Cinnamon Oil Membrane Wound Dressing via In situ Electrospinning Process

QIN Mei¹, LIU Daqing¹, DAI Zhang¹, MENG Xin¹, LIU Guosai¹, LIU Hao¹, HUANG Xiaowei³, YAN Xu^1,2,3, CHEN Shaojuan¹

1. Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles & Clothing, Shandong Center for Engineered Nonwovens, Qingdao University, Qingdao 266071, P. R. China;
2. State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, P. R. China;
3. Collaborative Innovation Center for Eco-Textiles of Shandong Province, Qingdao University, Qingdao 266071, P. R. China

Received:2021-01-27 Revised:2021-03-27 Online:2021-06-01 Published:2021-05-31
Contact: YAN Xu, CHEN Shaojuan E-mail:qdyanx@qdu.edu.cn;qdchshj@126.com
Supported by:
This work was supported by the Postdoctoral Science Foundation of China(No. 2020M671998), the Fund of the State Key Laboratory of Bio-Fibers and Eco-Textiles(Qingdao University) of China(No.ZKT35), and the National Natural Science Foundation of China(No.51703102).

Abstract

Abstract: Antibacterial wound dressing can benefit the wound healing by preventing bacterial infection, especially for the electrospun ones due to their porous structures and easily loading antibacterial drugs. However, it is challenging to apply the antibacterial electrospun wound dressing to covering the wound conveniently and safely. Here, we presented one step fabrication and application of antibacterial electrospun zein/cinnamon oil wound dressing via a handheld electrospinning setup. The prepared zein/cinnamon oil wound dressing showed gas permeability of (76.1±5.45) mm/s, hydrophilicity with zero body fluid contact angle, swelling stability after 24 h as well as antibacterial zones over 5 cm against both E. coli and S. aureus bacteria. Moreover, in situ electrospinning process can deposit the electrospun zein/cinnamon oil fibers directly onto the wound, meantime forming a wound dressing. The mice cut-wound model experiment demonstrated that the one step in situ fabrication and application of zein/cinnamon oil wound dressing could nearly heal the wound within 11 d.

Key words: In situ electrospinning, Antibacterial wound dressing, Zein, Cinnamon oil

QIN Mei, LIU Daqing, DAI Zhang, MENG Xin, LIU Guosai, LIU Hao, HUANG Xiaowei, YAN Xu, CHEN Shaojuan. One Step Fabrication and Application of Antibacterial Electrospun Zein/Cinnamon Oil Membrane Wound Dressing via In situ Electrospinning Process[J]. Chemical Research in Chinese Universities, 2021, 37(3): 464-469.

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One Step Fabrication and Application of Antibacterial Electrospun Zein/Cinnamon Oil Membrane Wound Dressing via In situ Electrospinning Process

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