β-Cyclodextrin Enhanced Fluorimetric Method for Determination of Amoxicillin in Dosage

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (2): 190-192.

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β-Cyclodextrin Enhanced Fluorimetric Method for Determination of Amoxicillin in Dosage

TANG Hui-nan¹, GENG Wei-dong², LIU Mou-sheng¹ and YANG Ya-ling^1*

1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, P. R. China;
2. Kunming Productivity Promotion Center, Kunming 650021, P. R. China

Received:2010-08-05 Revised:2010-10-26 Online:2011-03-25 Published:2011-03-09
Contact: YANG Ya-ling E-mail:yilyil8@163.com
Supported by:
Supported by the National Natural Science Foundation of China(No.40973081), the Foundation for Analysis and Measurement of Kunming University of Science and Technology, China(No.2009092) and the Innovation Fund for Small Technology Based Firms, China (No.10C26215305131).

Abstract

Abstract: A simple sensitive spectrofluorimetric method was developed for the determination of amoxicillin. Amoxicillin in the presence of formaldehyde produces a fluorescent pyrazine derivative, whose fluorescence intensity can be enhanced by forming an inclusion complex with β-cyclodextrin. Optimum conditions for the determination of amoxicillin were also investigated. Fluorimetric detection was carried out at λex=365 nm and λem=445 nm. The linear range of this method for the determination of amoxicillin is 0.1―10 mg/L and the limit of detection is 0.03 mg/L (IF=102.16ρ–9.6, r=0.9994). The developed method is practical and can be successfully applied to determine the content of amoxicillin in capsules and tablets with satisfactory results.

Key words: Fluorescence, Amoxicillin, β-Cyclodextrin, Inclusion complex

TANG Hui-nan, GENG Wei-dong, LIU Mou-sheng and YANG Ya-ling*. β-Cyclodextrin Enhanced Fluorimetric Method for Determination of Amoxicillin in Dosage[J]. Chemical Research in Chinese Universities, 2011, 27(2): 190-192.

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β-Cyclodextrin Enhanced Fluorimetric Method for Determination of Amoxicillin in Dosage

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