Synthesis of N-Succinyl-chitosan(Suc-Chi) and Preparation of Oxymatrine(OM)/N-Succinyl-chitosannanoparticles

Abstract

Abstract: Oxymatrine(OM)/N-succinyl-chitosan(Suc-Chi, with a degree of substitution being 0.32) was synthesized via the ring-opening reaction of succinic anhydride with chitosan in dimethyl sulfoxide. OM-loaded Suc-Chi nanoparticles were prepared by an ionotropic gelation process and OM was quantified via the HPLC method. The influences of the initial OM concentration on the nanoparticle characteristics and OM release behavior were evaluated. The nanoparticles were found to have a mean diameter within a range of 267—392 nm, a positive surface charge, and a zeta potential in the range of 19—27 mV. The formulation with an initial OM oncentration of 100 μg/mL provided the highest loaded capacity(0.77%) and the highest extent of the released OM(68% at 24 h), suggesting the possibility to achieve a therapeutic dose. According to the data obtained, this Suc-Chi-based nanotechnology will open up new and interesting prospects for the development of new anticancer drugs.

Key words: N-Succinyl-chitosan, Synthesis, Oxymatrine, Nanoparticles, Characterization

YAN Cheng-yun , CHEN Da-wei , GU Ji-wei , LI Liu-fa . Synthesis of N-Succinyl-chitosan(Suc-Chi) and Preparation of Oxymatrine(OM)/N-Succinyl-chitosannanoparticles
[J]. Chemical Research in Chinese Universities, 2006, 22(5): 589-592.

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Synthesis of N-Succinyl-chitosan(Suc-Chi) and Preparation of Oxymatrine(OM)/N-Succinyl-chitosannanoparticles

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