Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

Abstract

Abstract: A novel kind of acetohydroxyacid synthase(AHAS) inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized based on biorational design. The structures of these compounds were confirmed by IR, MS, NMR, and elemental analysis. The results of the preliminary activity tests indicate that most of the arylsulfonylamidecarbonyl-5-methyl-2-thiohydantoins have a higher biological activity than those without 5-methyl substituent.

Key words: Sulfonylaminocarbonyl-2-thiohydantoin, Sulfonylurea, Acetohydroxyacid synthase, Herbicidal activity, Sulfonylaminocarbonyl-2-thiohydantoin, Sulfonylurea, Acetohydroxyacid synthase, Herbicidal activity

GAO Fei-fei, LI Yao-xian, ZHANG Suo-qin , ZHANG Guang-liang. Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors[J]. Chemical Research in Chinese Universities, 2006, 22(5): 593-597.

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Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

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