Synthesis and Crystal Structure of N'-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide

Abstract

Abstract: N'-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide was synthesized by the reaction of 4-fluorobenzaldehyde with 2-(1H-1,2,4-triazole-1-yl)acetohydrazide. The structure was confirmed via elemental analysis, MS, ¹H NMR, IR, and X-ray diffraction. It crystallized in a monoclinic system with space group P2(1), a=0.4905(1) nm, b=0.8160(2) nm, c=1.4105(3) nm, β=93.33(3)°, Z=2, V=0.5636(2) nm³, D_c=1.457 Mg/m³, μ=0.112 mm^-1, F(000)=256, and final R₁=0.0685. Several intermolecular hydrogen-bond interactions existed in the crystal structure, facilitating the stabilization of the compound.

Key words: 1H-1,2,4-Triazole, Acetohydrazide, Crystal structure, Biological activity

LI Wei-hua , ZHANG Shu-fang , HOU Bao-rong , YU Zhi-gang. Synthesis and Crystal Structure of N'-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide[J]. Chemical Research in Chinese Universities, 2006, 22(5): 571-573.

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Synthesis and Crystal Structure of N'-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide

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