Synthesis, Structure and Biological Activities of 2-(4-Methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide

Abstract

Abstract: The title compound, 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was synthesized by several reactions from 4-methoxyacetophenone, triazole and phenyl isothiocyanate. The structure was identified by elemental analysis, ¹H NMR, MS and IR. The single crystal structure of 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide was determined with X-ray diffraction. The preliminary bioassays show that the title compound exhibits weak antifungal activities and plant-growth regulatory activity.

Key words: 1,2,4-Trizole, Thioamide, Crystal structure, Biological activities

LIU Fa-qian, QIN Yong-qi, LI Wei-hua, YANG Shuang-hua, LU Lu-de, YANG Xu-jie, WANG Xin, HOU Bao-rong. Synthesis, Structure and Biological Activities of 2-(4-Methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide[J]. Chemical Research in Chinese Universities, 2005, 21(3): 280-283.

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Synthesis, Structure and Biological Activities of 2-(4-Methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-1-yl)thioacetamide

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