Syntheses, Characterization and Anti-HIV Activity of Charge Transfer Heteropolycomplexes

Chemical Research in Chinese Universities ›› 2001, Vol. 17 ›› Issue (2): 127-133.

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Syntheses, Characterization and Anti-HIV Activity of Charge Transfer Heteropolycomplexes

LIU Shu-xia¹, LI Yang-guang¹, HAN Zeng-bo¹, HUANG Ru-dan¹, WANG En-bo¹, ZENG Yi², LI Ze-lin²

1. Chinese Academy of Preventive Medicine, Beijing 100050, P. R. China;
2. Department of Chemistry, Northeast Normal Univertsity, Changchun 130024, P. R. China

Received:1999-05-24 Online:2001-04-24 Published:2011-08-04
Supported by:
Supported by State Key Project(Granted:96-901-30A ).

Abstract

Abstract: Each of Keggin type heteropolytungstosilicic and heteropolytungstogermanic acids reacted with 8-quinolinol, p-aminodimethylaniline and pyridine, respectively, yielding six charge trans fer heteropolycomplexes(CTHPCs), which were purified and characterized by elemental analy sis, IR, UV and ¹⁸³W NMR. The anti-HIV-1 activities of CTHPCs were evaluated by ELISA of HIV-P24 antigen. The toxicity against MT-4 cells was measured by MTT. The results show that median inhibitory concentration(IC₅₀) for each CTHPC to inhibit HIV-P24 antigen in cell culture was lower than 5 g/mL, while median toxicity concentration (IC₅₀) against MT-4 cells was higher than 268 g/mL. The following mechanisms might be considered for their anti-HIV 1 activity, namely, (1) inhibiting the penetration of HIV-1 virus into target cells for it can blockade CD4 receptor of MT-4 cells and (2) inhibition of syncytium formation.

Key words: Heteropolycomplexes, Synthesis, Anti-HIV activity, Mechanism

LIU Shu-xia, LI Yang-guang, HAN Zeng-bo, HUANG Ru-dan, WANG En-bo, ZENG Yi, LI Ze-lin . Syntheses, Characterization and Anti-HIV Activity of Charge Transfer Heteropolycomplexes[J]. Chemical Research in Chinese Universities, 2001, 17(2): 127-133.

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Syntheses, Characterization and Anti-HIV Activity of Charge Transfer Heteropolycomplexes

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