Chemical Research in Chinese Universities ›› 2001, Vol. 17 ›› Issue (1): 69-72.

• Articles • Previous Articles     Next Articles

Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

LEI Ying-jie, ZHU Chun-hua, WANG Zuo-quan, LIU Hong   

  1. Xi'an Modern Chemistry Research Institute, Xi'an 710065, P. R. China
  • Received:1999-12-22 Online:2001-01-24 Published:2011-08-04

Abstract: The improved 3-step preparation of a key antitumor agent, 7-ethyl-10-hydroxycamptothecin(SN-38), which consists of ethylation, oxidation and photo-chemical rearrangement, is described. The proposed reaction mechanism is also discussed.

Key words: 7-Ethyl-10-hydroxycamptothecin(SN-38), Mechanism, Synthesis