Synthesis and Structure of R- ( + )-CamphorDerived N-Propionyl Sultam

Chemical Research in Chinese Universities ›› 1995, Vol. 11 ›› Issue (1): 32-38.

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Synthesis and Structure of R- ( + )-CamphorDerived N-Propionyl Sultam

HUANG Jin-xia¹, PAN Yi-Jun¹, XU Zhang-huang¹, CHEN Liao-rong², LUO Bao-sheng²

1. Deparinient of Chemistry, Hubei University, Wuhan, 430062;
2. Analysis and Testing Center, Wuhan University, 430072

Received:1994-03-21 Online:1995-01-24 Published:2011-08-17
Supported by:
Supported by the National Natural Science Foundation of China.

Abstract

Abstract: A potential chiral auxilliary, (+)-camphor derived N-propionyl sultam, wassynthesized from (+ )-camphor-10-sulphonyl chloride in four steps with enan-tiomerical purity.The molecular and crystal structures of the title compound weredetermined by single crystal diffraction analysis.The crystal belongts to monoclin-ic, space group P2₁ with cell dimentions a= 1.0502(4), b= 0.7252(1 ), c= 0.9363(2) nm, β= 108.3(5), V = 0.677 nm³, F(000) = 292 and Z= 2.The structuralcharacteristics with respect to the potential utility for the stereoselective alkylationat a-carbon of the N-propionyl group are discussed and explained based on ¹H-, ¹³C-NMR.MS and X-ray analysis.

Key words: N-Propionyl sultam, Potential chiral, Crystal structure

HUANG Jin-xia, PAN Yi-Jun, XU Zhang-huang, CHEN Liao-rong, LUO Bao-sheng. Synthesis and Structure of R- ( + )-CamphorDerived N-Propionyl Sultam[J]. Chemical Research in Chinese Universities, 1995, 11(1): 32-38.

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Synthesis and Structure of R- ( + )-CamphorDerived N-Propionyl Sultam

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