Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes

doi:10.1007/s40242-024-3262-y

Abstract

Abstract: Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility, but their water solubility negates the possibility to be used as a wound dressing. In this work, the problem of PVP dissolving in water was solved by the method of thermally crosslinking, and it was found that the thermally crosslinked PVP nanofiber heated at 170 ℃ for 6 h had good liquid absorption capacity, stability and good fiber morphology. In addition, the thermally crosslinked PVP nanofiber is complexed with I₂ to endow it with excellent antibacterial properties. It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments, which provides the possibility for it to be a dressing for the treatment of infectious wounds.

Key words: Electrospinning, Nanofiber membrane, Thermally crosslinked polyvinylpyrrolidone (PVP), Antimicrobial, Biocompatibility

XU Dejun, HE Liu, ZENG Fudong, LIU Bo, MA Jinli, HAN Dongmei, YANG Qingbiao, DU Jianshi. Study on Antibacterial and Biocompatibility of Thermally Crosslinked Polyvinylpyrrolidone Nanofiber Iodine Complexes[J]. Chemical Research in Chinese Universities, 2024, 40(6): 1050-1059.

References

[1] Formhals A., Process and Apparatus for Preparing Artificial Threads, US1975504A, 1934
[2] Li Y., Liu S., Zhao H., Guo L., Chem. Res. Chinese Universities, 2022, 38, 763.
[3] Guan J., Sun Z., Chem. Res. Chinese Universities, 2023, 39, 741.
[4] Wu L., Song Y., Xing S., Li Y., Xu H., Yang Q., Li Y., RSC Adv., 2022, 12, 34866.
[5] Aravindan V., Sundaramurthy J., Suresh Kumar P., Lee Y-S., Ramakrishna S., Madhavi S., Faraday Discuss. R. Soc. Chem., 2015, 51, 2225.
[6] Li J., Jiang Y., Yang J., Sun Y., Ma P., Song D., Chem. Res. Chinese Universities, 2022, 38, 790.
[7] Ladd M. R., Lee S. J., Stitzel J. D., Atala A., Yoo J. J., Biomaterials, 2011, 32, 1549.
[8] Wei Z., Liu Y., Wang F., Liu K., Zhang H., Chem. Res. Chinese Universities, 2023, 39, 545.
[9] Quirós J., Borges J. P., Boltes K., Rodea-Palomares I., Rosal R., J. Hazard. Mater., 2015, 299, 298.
[10] Kurakula M., Rao G. S. N. K., J. Drug Delivery Sci. Technol., 2020, 60, 102046.
[11] Pfaller M. A., Am. J. Med., 2012, 125, S3.
[12] Cantas L., Shah S. Q. A., Cavaco L. M., Manaia C. M., Walsh F., Popowska M., Garelick H., Bürgmann H., Sørum H., Front. Microbiol., 2013, 4, 00096.
[13] Souza S. O. L., Cotrim M. A. P., Oréfice R. L., Carvalho S. G., Dutra J. A. P., de Paula Careta F., Resende J. A., Villanova J. C. O., J. Mater. Sci.: Mater. Med., 2018, 29, 67.
[14] Singh S., J. Nanosci. Nanotechnol., 2010, 10, 7906.
[15] Nasouri K., Shoushtari A. M., Mojtahedi M. R. M., Fibers Polym., 2015, 16, 1941.
[16] Lin Y. C., Hu S. C. S., Huang P. H., Lin T. C., Yen F. L., Pharmaceutics., 2020, 12, 552.
[17] Fischer F., Bauer S., Chem. Unserer Zeit., 2009, 43, 376.
[18] Reddy N., Reddy R., Jiang Q., Trends Biotechnol., 2015, 33, 362.
[19] Tillet G., Boutevin B., Ameduri B., Prog. Polym. Sci., 2011, 36, 191.
[20] Raut P. W., Khandwekar A. P., Sharma N., J. Mater. Sci.: Mater. Med., 2018, 53, 11176.
[21] Liu G. S., Yan X., Yan F. F., Chen F. X., Hao L. Y., Chen S. J., Lou T., Ning X., Long Y. Z., Nanoscale Res. Lett., 2018, 13, 2777.
[22] Summa M., Russo D., Penna I., Margaroli N., Bayer I. S., Bandiera T., Athanassiou A., Bertorelli R., Eur. J. Pharm. Biopharm., 2018, 122, 17.
[23] Wang J., Peng C., Chen Z., Sun S., Shi Z., Jin L., Zhao W., Zhao C., Colloids Surf. B, 2019, 181, 918.
[24] Ignatova M., Manolova N., Rashkov I., Eur. Polym. J., 2007, 43, 1609.
[25] Maciejewska B. M., Wychowaniec J. K., Woźniak-Budych M., Popenda Ł., Warowicka A., Golba K., Litowczenko J., Fojud Z., Wereszczyńska B., Jurga S., Sci. Technol. Adv. Mater., 2019, 20, 979.
[26] Matos R. J. R., Silva J. C., Soares P. I. P., Borges J. P., Biomimetics., 2023, 8, 206.
[27] Melike G., Calisir M. D., Akgul Y., Selcuk S., Ali D., Kilic A., J. Ind. Text., 2019, 50, 1545.
[28] Lapuk S., Ponomareva M., Ziganshin M., Larionov R., Mukhametzyanov T., Schick C., Lounev I., Gerasimov A., Phys. Chem. Chem. Phys., 2023, 25, 10706.
[29] Austero M. S., Donius A. E., Wegst U. G. K., Schauer C. L., J. R. Soc. Interface. 2012, 9, 2551.
[30] Sarhan W. A., Azzazy H. M. E., Carbohydr. Polym., 2015, 122, 135.
[31] Yao C., Li X., Neoh K. G., Shi Z., Kang E. T., J. Membr. Sci., 2008, 320, 259.
[32] Qiu J-H., Zhang Y-W., Zhang Y-T., Zhang H-Q., Liu J-D., J. Colloid Interface Sci., 2011, 354, 152.
[33] Zhang X., Lv R., Chen L., Sun R., Zhang Y., Sheng R., Du T., Li Y., Qi Y., ACS Appl. Mater. Interfaces. 2022, 14, 12984.
[34] Zhang Z., Wu Y., Wang Z., Zou X., Zhao Y., Sun L., Mater. Sci. Eng. C, 2016, 69, 462.
[35] Raczkowska J., Stetsyshyn Y., Awsiuk K., Brzychczy-Włoch M., Gosiewski T., Jany B., Lishchynskyi O., Shymborska Y., Nastyshyn S., Bernasik A., Ohar H., Krok F., Ochońska D., Kostruba A., Budkowski A., Mater. Sci. Eng. C, 2019, 103, 109806.
[36] Li D., Gao Y., Wang Y., Yang X., He C., Zhu M., Zhang S., Mo X., J. Biomater. Appl., 2019, 33, 1118.
[37] Steins A., Carroll C., Choong F. J., George A. J., He J. S., Parsons K. M., Feng S., Man S. M., Kam C., van Loon L. M., Poh P., Ferreira R., Mann G. J., Gruen R. L., Hannan K. M., Hannan R. D., Schulte K.-M., Life Sci. Alliance., 2023, 6, e202201875.
[38] Zhou L., Cai L., Ruan H., Zhang L., Wang J., Jiang H., Wu Y., Feng S., Chen J., Int. J. Biol. Macromol., 2021, 183, 1145.
[39] Narayanan V., Sumathi S., Polym. Bull., 2018, 76, 2777.
[40] Zhou F., Cui C., Sun S., Wu S., Chen S., Ma J., Li C. M., Carbohydr. Polym., 2022, 282, 119131.
[41] Haghi A. K., Akbari M., Phys. Status Solidi. A, 2007, 204, 1830.
[42] Newsome T. E., Olesik S. V., J. Appl. Polym. Sci., 2014, 131, 40966.
[43] Hatch K. M., Hlavatá J., Paulett K., Liavitskaya T., Vyazovkin S., Stanishevsky A. V., Int. J. Polym. Sci., 2019, 2019, 1.
[44] Jablonski A. E., Lang A. J., Vyazovkin S., Thermochim. Acta, 2008, 474, 78.
[45] Xu X., Guan Y., Ind. Eng. Chem. Res., 2020, 59, 22667.
[46] Edis Z., Bloukh S. H., Biomimetics. 2020, 5, 45.
[47] Gao B., Wang Z., Liu Q., Du R., Colloids Surf. B, 2010, 79, 446.
[48] Uetani K., Okada T., Oyama H. T., Biomacromolecules. 2015, 16, 2220.
[49] Zhang Q. G., Hu W. W., Zhu A. M., Liu Q. L., RSC Adv., 2013, 3, 1855.
[50] Zheng F., Wang S., Wen S., Shen M., Zhu M., Shi X., Biomaterials, 2013, 34, 1402.
[51] Tiller J. L, CJ; Lewis K., Klibanov A. M., Proc. Natl. Acad. Sci., 2001, 98, 5981.
[52] Hu F. X., Neoh K. G., Cen L., Kang E. T., Biotechnol. Bioeng., 2004, 89, 474.
[53] Quirós J., Boltes K., Aguado S., de Villoria R. G., Vilatela J. J., Rosal R., Chem. Eng. J., 2015, 262, 189.
[54] Abueva C., Ryu H. S., Min J. W., Chung P. S., You H. S., Yang M. S., Woo S. H., Int. J. Biol. Macromol., 2021, 182, 1713.