Differential Antibacterial Effects of Chiral Co3O4

doi:10.1007/s40242-024-4036-2

Chemical Research in Chinese Universities ›› 2024, Vol. 40 ›› Issue (6): 1134-1140.doi: 10.1007/s40242-024-4036-2

• Articles • Previous Articles Next Articles

Differential Antibacterial Effects of Chiral Co₃O₄

SUN Jia^1,2, SONG Shanshan^1,2, GUO Caoyu^1,2, LIU Liqiang^1,2, SUN Maozhong^1,2, KUANG Hua^1,2, XU Chuanlai^1,2, GUO Lingling^1,2

1. State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, P. R. China;
2. International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China

Received:2024-02-22 Online:2024-12-01 Published:2024-10-26
Contact: GUO Lingling,gling0329@jiangnan.edu.cn E-mail:gling0329@jiangnan.edu.cn
Supported by:
This work was supported by the National Key R&D Program of China (No. 2022YFF1102600).

Abstract

Abstract: With the global spread of antimicrobial resistance, it is imperative to satisfy the need to develop novel antibacterial agents. Here, we synthesized chiral Co₃O₄ nanoparticles (NPs) with obvious bactericidal effects. It was found that the circular dichroism (CD) spectra of L-Co₃O₄ NPs and D-Co₃O₄ NPs exhibited perfect mirror image inversion. Specifically, the survival rate of primary uterine fibroblast (PCS) cells reached above 90% by co-culturing with chiral Co₃O₄ NPs. Besides, the chiral Co₃O₄ NPs showed obvious killing ability on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli O157:H7) bacteria both in vitro and in vivo. Particularly, D-Co₃O₄ NPs showed better antibacterial activity. Mechanistic studies confirmed that the level of reactive oxygen species level generated by D-Co₃O₄ NPs was higher than that of L-Co₃O₄ NPs. Overall, the synthesized D-Co₃O₄ NPs have the potential to become a kind of novel antibacterial nanomaterials.

Key words: Chiral material, Antibacterial property, Co₃O₄, Antimicrobial resistance

SUN Jia, SONG Shanshan, GUO Caoyu, LIU Liqiang, SUN Maozhong, KUANG Hua, XU Chuanlai, GUO Lingling. Differential Antibacterial Effects of Chiral Co₃O₄[J]. Chemical Research in Chinese Universities, 2024, 40(6): 1134-1140.

References

[1] Larsson D. G. J., Flach C.-F., Nat. Rev. Microbiol., 2022, 20, 257.
[2] Wang Y., Yang Y., Shi Y., Song H., Yu C., Adv. Mater., 2020, 32, 1904106.
[3] Xin Q., Shah H., Nawaz A., Xie W., Akram M. Z., Batool A., Tian L., Jan S. U., Boddula R., Guo B., Liu Q., Gong J. R., Adv. Mater., 2019, 31, 1804838.
[4] Li C., Li Z., Zeng Y., Cao X., Zhao H., Yang Y. Y., Yuan P., Lu X., Ding X., Adv. Healthc. Mater., 2022, 11, 2102044.
[5] Liu Y., Zhao X., Zhang X.-S., Jia X., Wu L., Jiang X., Chin. J. Chem., 2023, 41, 2132.
[6] Ye L., Cao Z., Liu X., Cui Z., Li Z., Liang Y., Zhu S., Wu S., J. Alloys Compd., 2022, 904, 164091.
[7] Tang Y., Qin Z., Yin S., Sun H., Nanoscale, 2021, 13, 6373.
[8] Wang Z., Zhu J., Chen L., Deng K., Huang H., ACS Appl. Mater. Interfaces, 2023, 15, 40241.
[9] Yang Y., Deng Y., Huang J., Fan X., Cheng C., Nie C., Ma L., Zhao W., Zhao C., Adv. Funct. Mater., 2019, 29, 1900143.
[10] Huang S., Yan L., Chen X., Zhu J.-J., Chin. J. Chem., 2023, 41, 2354.
[11] Li J., Pan G., Zyryanov G. V., Peng Y., Zhang G., Ma L., Li S., Chen P., Wang Z., ACS Appl. Mater. Interfaces, 2023, 15, 40864.
[12] Xie M., Gao M., Yun Y., Malmsten M., Rotello V. M., Zboril R., Akhavan O., Kraskouski A., Amalraj J., Cai X., Lu J., Zheng H., Li R., Angew. Chem. Int. Ed., 2023, 62, e202217345.
[13] Weiss C., Diabaté S., Nanomaterials (Basel, Switzerland), 2021, 11, 3110.
[14] Ma B., Bianco A., Nature Reviews Materials, 2023, 8, 403.
[15] Duan Y., Che S., Adv. Mater., 2023, 35, 2205088.
[16] Xu L., Wang X., Wang W., Sun M., Choi W. J., Kim J.-Y., Hao C., Li S., Qu A., Lu M., Wu X., Colombari F. M., Gomes W. R., Blanco A. L., de Moura A. F., Guo X., Kuang H., Kotov N. A., Xu C., Nature, 2022, 60, 366.
[17] Sun M., Wang X., Guo X., Xu L., Kuang H., Xu C., Chem. Sci., 2022, 13, 3069.
[18] Liu Y., Wu Z., Armstrong D. W., Wolosker H., Zheng Y., Nat. Rev. Chem., 2023, 7, 355.
[19] Li C., Li S., Zhao J., Sun M., Wang W., Lu M., Qu A., Hao C., Chen C., Xu C., Kuang H., Xu L., J. Am. Chem. Soc., 2022, 144, 1580.
[20] Zhong Y., Chen Y., Chen L., Hu Y., Xiao X., Xia L., Li G., Anal. Chem., 2023, 95, 6971.
[21] Zhang G., Liang Y., Wang Y., Li Q., Qi W., Zhang W., Su R., He Z., ACS Nano, 2022, 16, 6866.
[22] Niu X., Zhao R., Yan S., Pang Z., Li H., Yang X., Wang K., Small, 2023, 19, 2303059.
[23] Chen P., Wang G., Hao C., Ma W., Xu L., Kuang H., Xu C., Sun M., Chem. Sci., 2022, 13, 10281.
[24] Wang G., Hao C., Chen C., Kuang H., Xu C., Xu L., Small, 2022, 18, 2204219.
[25] Wang X., Sun M., Qu A., Wang W., Lu M., Guo X., Chen C., Hao C., Xu L., Xu C., Kuang H., Angew. Chem. Int. Ed., 2021, 60, 18240.
[26] Gao H., Sun M., Duan Y., Cai Y., Dai H., Xu T., Int. J. Biol. Macromol., 2023, 246, 125596.
[27] Kavitha T., Haider S., Kamal T., Ul-Islam M., J. Alloys Compd., 2017, 704, 296.

Differential Antibacterial Effects of Chiral Co₃O₄

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 5

Recommended Articles

Metrics

Comments

[1]	LI Wenfeng, FANG Xue, LYU Jiahui, WANG Guowen, MA Chun, MA Hongchao. Co₃O₄ Decorated Ti/TiO₂ Nanotubes for Photogenerated Cathodic Protection of 304 Stainless Steel [J]. Chemical Research in Chinese Universities, 2021, 37(3): 704-710.
[2]	LEI Huijin, ZHANG Xinlu, JIN Jiongke, WANG Shuhua, DING Shunmin, ZHANG Ning, CHEN Chao. Highly Uniform Alkali Doped Cobalt Oxide Derived from Anionic Metal-Organic Framework: Improving Activity and Water Tolerance for CO Oxidation [J]. Chemical Research in Chinese Universities, 2020, 36(5): 946-954.
[3]	WANG Chen, MENG Yanshuang, WANG Lei, ZHU Fuliang, ZHANG Yue. One Step Hydrothermal Synthesis of Flower-shaped Co₃O₄ Nanorods on Nickel Foam as Supercapacitor Materials and Their Excellent Electrochemical Performance [J]. Chemical Research in Chinese Universities, 2018, 34(6): 882-886.
[4]	LIU Shankui, LIU Pengcheng, NIU Ruyue, WANG Shuang, LI Jinping. Facile Synthesis of Mesoporous Co₃O₄ Nanoflowers for Catalytic Combustion of Ventilation Air Methane [J]. Chemical Research in Chinese Universities, 2017, 33(6): 965-970.
[5]	JIA Yongchang, WANG Shuyuan, LU Jiqing, LUO Mengfei. Effect of Structural Properties of Mesoporous Co₃O₄ Catalysts on Methane Combustion [J]. Chemical Research in Chinese Universities, 2016, 32(5): 808-811.