Chemical Research in Chinese Universities ›› 2023, Vol. 39 ›› Issue (1): 42-60.doi: 10.1007/s40242-023-2334-8

• Review • Previous Articles     Next Articles

Construction and Application of DNAzyme-based Nanodevices

WANG Bo1, WANG Menghui1, PENG Fangqi1, FU Xiaoyi3, WEN Mei1, SHI Yuyan1, CHEN Mei2, KE Guoliang1, ZHANG Xiao-Bing1   

  1. 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China;
    2. College of Materials Science and Engineering, Hunan University, Changsha, 410082, P. R. China;
    3. Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, 310022, P. R. China
  • Received:2022-12-09 Online:2023-02-01 Published:2023-02-02
  • Contact: KE Guoliang, ZHANG Xiao-Bing E-mail:glke@hnu.edu.cn;xbzhang@hnu.edu.cn
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (Nos.22122403, 22274042, and 21890744), the Natural Science Foundation of Hunan Province, China(Nos.2021JJ10012, 2022JJ30121) and the Changsha Municipal Natural Science Foundation, China(No.kq2202145).

Abstract: The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.

Key words: DNAzyme, Nanodevice, Biosensor, Therapy