Chemical Research in Chinese Universities ›› 2022, Vol. 38 ›› Issue (2): 481-492.doi: 10.1007/s40242-021-1315-z

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Magnetic-Optical Imaging for Monitoring Chemodynamic Therapy

WANG Youjuan1, YE Zhifei1, SONG Guosheng1, LIU Zhuang2   

  1. 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China;
    2. Institute of Functional Nano & Soft Materials(FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, P. R. China
  • Received:2021-08-13 Revised:2021-08-29 Online:2022-04-01 Published:2022-05-18
  • Contact: SONG Guosheng, LIU Zhuang E-mail:songgs@hnu.edu.cn;zliu@suda.edu.cn
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (Nos.21804039 and 51872088), the Science and Technology Project of Hunan Province, China(No.2020RC3022), and the Fundamental Research Funds for the Central Universities, China.

Abstract: Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment. Although chemodynamic therapy is blossoming in recent years, their therapy process still faces a series of hampers. The unknown catalytic activity of chemodynamic therapy reagents may lead to unpredictable therapy effects, so it is necessary to reveal the therapeutic mechanism of chemodynamic therapy and develop self-monitoring probes. In this mini-review, we summarize and illustrate the most recent progress of chemodynamic therapy, focusing on the applications of magnetic imaging and optical imaging probe for monitoring cancer chemodynamic therapy. Furthermore, we also discuss the potential challenges and the further directions of this field.

Key words: Chemodynamic therapy, Magnetic imaging, Optical imaging, Nanoprobe, Monitoring therapeutic response