Disulfide-crosslinked Poly(L-glutamic acid) Grafted Mesoporous Silica Nanoparticles and Their Potential Application in Drug Delivery

doi:10.1007/s40242-015-5075-5

Chemical Research in Chinese Universities ›› 2015, Vol. 31 ›› Issue (5): 890-894.doi: 10.1007/s40242-015-5075-5

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Disulfide-crosslinked Poly(L-glutamic acid) Grafted Mesoporous Silica Nanoparticles and Their Potential Application in Drug Delivery

WU Huiyong¹, LI Jianhui¹, WEI Junchao¹, DAI Yanfeng¹, PENG Zhiping¹, CHEN Yiwang¹, LIU Tianxi^1,2

1. Department of Chemistry, Nanchang University, Nanchang 330031, P. R. China;
2. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China

Received:2015-03-02 Revised:2015-07-01 Online:2015-10-01 Published:2015-07-30
Contact: WEI Junchao, E-mail: weijunchao@ncu.edu.cn E-mail:weijunchao@ncu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.51203073, 51463013, 51263017) and the Natural Science Foundation of Jiangxi Province, China(Nos.20142BAB203018, 20151BAB206011).

Abstract

Abstract:

Poly(L-glutamic acid)(PLGA) was grafted onto the surface of mesoporous silica nanoparticles(MSN) via the ring opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride(BLG-NCA) and its subsequent deprotection of benzyl groups. The PLGA chains were cross-linked with cystamine, and thus forming a type of redox responsive drug delivery system(MSN-cPLGA). The structures were characterized by Fourier transform infrared spectrometry(FTIR), transmission electron microscopy(TEM) and energy disperse spectrometry(EDS), demonstrating that disulfide groups existed on the surfaces of MSN-cPLGA particles. The thermal gravimetric analysis(TGA) results show that the PLGA mass fraction is about 33.4% in the MSN-cPLGA hybrid. The in vitro drug release experiments showed that the MSN-cPLGA hybrid can realize the controlled release of model drugs(5-fluorouracil) in response to redox environment. Even 0.1 mmol/L dithiothreitol(DTT) can accelerate the drug release speed, and a concentration of 10.0 mmol/L DTT is higher enough to trigger the open of cross-linked PLGA network so as to realize rapid release of drugs. All the results demonstrate that the cross-linked PLGA chains on the surface of MSN could act as efficient gatekeepers to control the on-off of the pores, showing potential application in drug delivery system.

Key words: Mesoporous silica nanoparticle, Redox responsive, Drug delivery, Surface modification, Hybrid

WU Huiyong, LI Jianhui, WEI Junchao, DAI Yanfeng, PENG Zhiping, CHEN Yiwang, LIU Tianxi. Disulfide-crosslinked Poly(L-glutamic acid) Grafted Mesoporous Silica Nanoparticles and Their Potential Application in Drug Delivery[J]. Chemical Research in Chinese Universities, 2015, 31(5): 890-894.

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Disulfide-crosslinked Poly(L-glutamic acid) Grafted Mesoporous Silica Nanoparticles and Their Potential Application in Drug Delivery

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