Programmable and Reversible Regulation of Catalytic Hemin@MOFs Activities with DNA Structures

doi:10.1007/s40242-020-0110-6

Chemical Research in Chinese Universities ›› 2020, Vol. 36 ›› Issue (2): 301-306.doi: 10.1007/s40242-020-0110-6

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Programmable and Reversible Regulation of Catalytic Hemin@MOFs Activities with DNA Structures

LIU Shuo, YANG Mingjie, GUO Weiwei

College of Chemistry, Research Centre for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin 300071, P. R. China

Received:2019-12-25 Revised:2020-03-02 Online:2020-04-01 Published:2020-03-02
Contact: GUO Weiwei E-mail:weiweiguo@nankai.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21505078, 21874076), the Natural Science Foundation of Tianjin City, China(No.18JCZDJC37800), the Fundamental Research Funds for Central Universities(China) and the National Program for Support of Top-notch Young Professionals, China.

Abstract

Abstract: Metal-organic frameworks(MOFs)-based nanozyme plays an important role in biosensing, therapy and catalysis. In this study, the effects of single-stranded DNA(ssDNA) with programmable sequences and its complementary DNA(T_DNA) on the intrinsic peroxidase-like activity of hemin loaded MOFs(UiO-66-NH₂), denoted as hemin@UiO-66-NH₂, were investigated. The hemin@UiO-66-NH₂ exhibited improved catalytic activity compared with free hemin. However, the catalytic activity is inhibited in the presence of ssDNA, as ssDNA can be adsorbed by MOFs and therefore protected the active sites from contact with substrates. Upon the addition of the T_DNA, double-stranded DNA(dsDNA) was formed and detached from the MOFs, resulting in the recovery of catalytic activity. Sequentially adding ssDNA or its complementary DNA strands can achieve the reversible regulation of the catalytic activity of MOFs nanozymes. Moreover, the DNA hybridization-based regulation was further applied to a cascaded catalytic system composed of the nanozyme, hemin@UiO-66-NH₂, and glucose oxidase. These nanozyme based programmable and reversibly regulated catalytic systems may have potential applications in future smart biosensing and catalysis systems.

Key words: Nanozyme, Catalytic metal-organic framework, Hemin, DNA hybridization, Dynamic modification

LIU Shuo, YANG Mingjie, GUO Weiwei. Programmable and Reversible Regulation of Catalytic Hemin@MOFs Activities with DNA Structures[J]. Chemical Research in Chinese Universities, 2020, 36(2): 301-306.

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Programmable and Reversible Regulation of Catalytic Hemin@MOFs Activities with DNA Structures

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