Chemical Research in Chinese Universities ›› 2020, Vol. 36 ›› Issue (2): 211-218.doi: 10.1007/s40242-019-0038-x

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Programmable Assembly of DNA-protein Hybrid Structures

LI Xue, YANG Donglei, SHEN Luyao, XU Fan, WANG Pengfei   

  1. Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China
  • Received:2019-11-06 Revised:2019-11-26 Online:2020-04-01 Published:2019-11-27
  • Contact: WANG Pengfei E-mail:pengfei.wang@sjtu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.21974086).

Abstract: DNA is the genetic information carrier for most known living organisms on Earth, while proteins are the functional component that carry out most biological processes. Many natural machineries are DNA-protein hybrid complexes to cooperatively and efficiently conduct sophisticated biological tasks. It has drawn increasing interest to the research field to construct artificial DNA-protein hybrid structures towards a variety of applications including biological studies, nanofabrication, biomedical research, etc. In this regard, here in this report we reviewed the up-to-date progress on making DNA-protein hybrid structures, with a particular focus on DNA nanotechnology-enabled programmable assembly of DNA-protein hybrid structures.

Key words: DNA nanotechnology, Self-assembly, DNA-protein conjugation, DNA-protein hybrid structure