Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (3): 352-355.doi: 10.1007/s40242-014-3433-3

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Ternary Solid Nano Organic/Inorganic Composite of Lanthanum with Acetic Acid and Curcumin/Hydroxyapatite and Its Antibacterial Activity

WANG Chunyan1, LÜ Zhongwen2, YAN Wei3, ZENG Shangjing4, WANG Runwei4   

  1. 1. School of Public Health, Jilin University, Changchun 130021, P. R. China;
    2. China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;
    3. Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, P. R. China;
    4. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China
  • Received:2013-10-12 Revised:2014-01-20 Online:2014-06-01 Published:2014-05-24
  • Contact: WANG Chunyan, WANG Runwei E-mail:rwwang@jlu.edu.cn;chunyan@jlu.edu.cn
  • Supported by:

    Supported by the Technology Development Project Foundation of Jilin Province, China(Nos.20110940, 20130413059GH) and the 50th Post Doctor Science Foundation of China(No.2011M500600).

Abstract:

Ternary solid complex was synthesized via hybridization of curcumin(Cur), hydroxyapatite(HAP), lanthanum(La) and acetic acid(HAc). The nano-scale hybrid composite of La-Cur/HAP was directly prepared by the wet method. The morphologies and structures of the composite were characterized by scanning electron microscopy (SEM), infrared(IR) spectroscopy, X-ray diffraction(XRD), transmission electron microscopy(TEM) and energy dispersive X-ray spectroscopy. The antibacterial activities were tested by methods of minimum inhibitory concentration (MIC) and minimum bactericidal concentration(MBC). The results show that the size of the La-Cur/HAP composite is less than 100 nm, and the composite exhibits strong bacteriostatic activity against Escherichia coli(E. coli) and Staphylococcus aureus(S. aureus) at low concentrations(in the range of 26―92 μg/mL). The composite can exhibit both of the bacteria and shows higher antibacterial activity against S. aureus than against E. coli. At the same time, La-Cur/HAP shows stronger antibacterial efficiency than ampicillin/HAP.

Key words: Curcumin, Lanthanum, Hydroxyapatite, Antibacterial activity