Synthesis of Fluorinated Urchin-like Serried Hydroxyapatite with Improved Water Sorption-Solubility and Bioactivity for Dental Composites

doi:10.1007/s40242-021-1268-2

Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (5): 1092-1100.doi: 10.1007/s40242-021-1268-2

• Articles • Previous Articles Next Articles

Synthesis of Fluorinated Urchin-like Serried Hydroxyapatite with Improved Water Sorption-Solubility and Bioactivity for Dental Composites

CHEN Hongyan, WANG Junjun, WANG Ruili, ZHU Meifang

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. China

Received:2021-07-14 Revised:2021-08-09 Online:2021-10-01 Published:2021-08-23
Contact: WANG Ruili E-mail:wangruili@dhu.edu.cn
Supported by:
This work was supported by the National Key Research and Development Program of China(No.2016YFA0201702/2016YFA0201700), the National Natural Science Foundation of China(No.51903042), the Graduate Student Innovation Fund of Donghua University, China(No.CUSF-DH-D-2019019), and the Project of the International Joint Laboratory for Advanced Fiber and Low-Dimension Materials, China(No.18520750400).

Abstract

Abstract: Fluorine is present in the hydroxyapatite mineral in natural tooth enamel, which plays a key role in the prevention of dental caries. The aim of this study is to synthetize the fluorinated urchin-like serried hydroxyapatite(FnUHA) particles with different degrees of fluorine substitution and explore the effect of the fluorine element on the water absorption-solubility, mechanical strength, and biological activity of dental composites. The obtained FnUHA particles were further modified with 3-methacryloxypropyl trimethoxysilane(γ-MPS) to get the silanized FnUHA(SFnUHA) particles, which were then used as the reinforcement for dental composites. The morphology, compositional elements, and structure of the FnUHA were characterized by field-emission scanning electron microscopy(FE-SEM), transmission electron microscopy(TEM), X-ray photoelectron spectroscopy(XPS), X-ray diffractometer(XRD), and Fourier transform infrared spectrometer (FTIR), respectively. The mechanical properties of the SFnUHA reinforced composites with different filler loadings were measured with a universal testing machine. The results demonstrated that the 50%(mass fraction) SF5UHA filled composite exhibited the acceptable flexural strength and compressive strength, giving the respective improvements of 56.3% and 30.8% compared with those of the 50% SUHA filled composite. In addition, this composite also presented lower water absorption-solubility, better in vitro bioactivity, and excellent cell viability. Therefore, fluorinated hydroxyapatite is a promising filler to improve the mechanical properties and functionality of dental composites.

Key words: Fluorinated hydroxyapatite, Dental composite, Mecha-nical property, Water absorption, In vitro bioactivity, Cell viability

CHEN Hongyan, WANG Junjun, WANG Ruili, ZHU Meifang. Synthesis of Fluorinated Urchin-like Serried Hydroxyapatite with Improved Water Sorption-Solubility and Bioactivity for Dental Composites[J]. Chemical Research in Chinese Universities, 2021, 37(5): 1092-1100.

References

[1] Stewart C. A., Finer Y., Dent. Mater., 2019, 35, 36
[2] Mjör I. A., Moorhead J. E., J. Am. Coll. Dent., 1998, 65, 27
[3] Cho K., Yasir. M., Jung M., Willcox M. D., Stenzel M. H., Rajan G., Farrar P., Prusty B. G., Compos. Part B:Eng., 2020, 202, 108448
[4] Yadav R., Kumar M., J. Compos. Mater., 2020, 54, 2623
[5] Zhao M. L., Geng Y. N., Fan S. N., Yao X., Zhu M. F., Zhang Y. P., Compo. Sci. Technol., 2021, 213, 108902
[6] Nedeljkovic I., De Munck. J., Vanloy A., Declerck D., Lambrechts P., Peumans M., Teughels W., Van Meerbeek B., Van Landuyt K. L., Clin. Oral Investig., 2020, 24, 683
[7] Xu H. H., Quinn J. B., Smith D. T., Antonucci J. M., Schumacher G. E., Eichmiller F. C., Biomaterials, 2002, 23, 735
[8] Chen H. Y., Wang R. L., Qian L., Liu H. M., Wang J. X., Zhu M. F., Compos. Part B:Eng., 2020, 182, 107621
[9] Singh A., Banerjee S. L., Dhiman V., Bhadada S. K., Sarkar P., Khamrai K., Kumari K., Kundu P. P., Polymer, 2020, 195, 122436
[10] Weiss P., Obadia L., Magne D., Bourges X., Rau C., Weitkamp T., Khairoun I., Bouler J. M., Chappard D., Gauthier O., Daculsi G., Biomaterials, 2003, 24, 4591
[11] Labella R., Braden M., Deb S., Biomaterials, 1994, 15, 1197
[12] Zhang H., Darvel B., Dent. Mater., 2012, 28, 824
[13] Li J. H., Zheng H., Lin H. X., Zhang B. X., Wang J. B., Li T. L., Zhang Q. Q.,Chinese J. Polym. Sci., 2019, 37, 1234
[14] Qian L., Wang R. L., Li W., Chen H. Y., Jiang X. Z., Zhu M. F., Macromol. Mater. Eng., 2019, 1800738
[15] Pajor K., Pajchel L., Kolmas J., Materials, 2019, 12, 2683
[16] Chen H. F., Sun K., Tang Z. Y., Law R. V., Mansfield J. F., Clarkson B. H., Cryst. Growth Des., 2006, 6, 1504
[17] Rameshbabu N., Kumar T. S., Rao K. P., Bull. Mater. Sci., 2006, 29, 611
[18] Moreno E., Kresak M., Zahkadnik R., Nature, 1974, 247, 64
[19] Liu F. W., Wang R. L., Cheng Y. H., Jiang X. Z., Zhang Q. H., Zhu M. F., Mater. Sci. Eng. C, 2013, 33, 4994
[20] Chen H. Y., Wang R. L., Zhang J. D., Hua H, F., Zhu M. F., Dent. Mater., 2018, 34, 1846
[21] Chen H. Y., Wei S. Q., Wang R. L., Zhu M. F., ACS Biomater. Sci. Eng., 2021, 7, 1428
[22] International Organization for Standardization, ISO 4049, Dentistry-Polymer-Based Restorative Materials, 2009
[23] Liu F. W., Jiang X. Z., Bao S., Wang R. L., Sun B., Zhu M. F., Mater. Sci. Eng. C, 2015, 53, 150
[24] International Organization for Standardization, ISO 10993-5, Biological Evaluation of Medical Devices-Part 5:Tests for in Vitro Cytotoxicity, 2009
[25] Chen H. Y., Liu H. M., Wang R. L., Jing X. Z., Zhu M. F., Dent. Mater., 2021, 37, 961
[26] Guo X. L., Rao Q.L., Li L. L., China Ceramics, 2016, 52, 44
[27] Freund F., Knobel R. M., J. Chem. Soc., Dalton Trans., 1977, 11, 1136
[28] Meng F. B., Zhao R., Zhan Y. Q., Liu X. B., J. Mater. Chem., 2011, 21, 16385
[29] Wang Y., Shi J., Han L., Xiang F. M., Mater. Sci. Eng., A:Struct., 2009, 501, 220
[30] Xu H. H., Martin T. A., Antonucci J. M., Eichmiller E. C., J. Dent. Res., 1999, 78, 706
[31] Liu F. W., Jiang X. Z., Zhang Q. H., Zhu, M. F., Compo. Sci. Technol., 2014, 101, 86
[32] Santos C., Clarke R. L., Braden M., Guitian F., Davy K. W., Biomaterials, 2002, 23, 1897
[33] Clarkson B. H., Adv. Dent. Res., 1991, 5, 41
[34] Robinson C., Connell S., Kirkham J., Brookes S. J., Shore R. C., Smit A. M., Caries Res., 2004, 38, 268
[35] Moreno E., Kresak M., Zahkadnik R., Nature, 1974, 247, 64
[36] Lööfa J., Svahn F., Jarmar T., Engqvist H., Pameijer C. H., Dent. Mater., 2008, 24, 653
[37] Peters M. C., Bresciani E., Barata T. J., Fagundes T. C., Navarro R. L., Navarro M. F., Dickens S. H., J. Dent. Res., 2010, 89, 28
[38] Liu F. W., Hu J. H., Wang R. L., Pan Y. Y., Jiang X. Z., Zhu M. F., Mater. Sci. Forum, 2013, 745, 466
[39] Li X. K., Wang J. F., Joiner A., Chang J., J.Dent., 2014, 42, S12
[40] Tredwin T. W., Young A. M., Neel E. A., Georgiou G., Knowles J. C., J. Mater. Sci:Mater. Med., 2014, 25, 47

Synthesis of Fluorinated Urchin-like Serried Hydroxyapatite with Improved Water Sorption-Solubility and Bioactivity for Dental Composites

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 3

Recommended Articles

Metrics

Comments

[1]	LI Yan-bo, ZHANG Hai-xia, GUO Cai-xia, HU Gui-qin, DU Hai-ying, JIN Ming-hua, HUANG Pei-li, SUN Zhi-wei, YANG Wen-sheng. Cytotoxicity and DNA Damage Effect of TGA-capped CdTe Quantum Dots [J]. Chemical Research in Chinese Universities, 2012, 28(2): 276-281 .
[2]	LIU Jun-song,5 , YANG Jin-gang , HONG Yuan , JIN Feng-hai , WANG Ming-cui , ZHAO Shu-hua , FANG Xue-xun . Inhibitory Effects of Polygoni Multiflori Caulis Extracts on Matrix Metalloproteinase Activities [J]. Chemical Research in Chinese Universities, 2009, 25(2): 211-215.
[3]	X. Xu, Z. F. Cui. Effects of Cryoprotective Agents on the Bovine Articular Chondrocyte Viability [J]. Chemical Research in Chinese Universities, 2002, 18(2): 109-112.