Novel Method to Graft Chitosan on the Surface of Hydroxyapatite Nanoparticles via “Click” Reaction

doi:10.1007/s40242-014-4166-z

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (6): 1063-1065.doi: 10.1007/s40242-014-4166-z

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Novel Method to Graft Chitosan on the Surface of Hydroxyapatite Nanoparticles via “Click” Reaction

WEI Junchao^1,2, GUO-WANG Peiyao¹, CUI Liguo³, ZHANG Haobin¹, DAI Yanfeng¹, LIU Tianxi^1,2

1. Department of Chemistry, Nanchang University, Nanchang 330031, P. R. China;
2. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China;
3. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2014-04-30 Revised:2014-08-18 Online:2014-12-01 Published:2014-09-09
Contact: WEI Junchao, LIU Tianxi E-mail:weijunchao@ncu.edu.cn;txliu@fudan.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.51203073, 51463013), the Natural Science Foundation of Jiangxi Province of China(No.20142BAB203018) and the Natural Science Foundation of Education Department of Jiangxi Province of China(No.GJJ13107).

Abstract

Abstract:

In order to tune the surface properties of hydroxyapatite(HA) nanoparticles and prevent them from aggregation, an efficient method was proposed to graft chitosan(CS) molecules on the surface of HA via “click” reaction. Thermal gravimetric analysis(TGA) shows that CS was successfully grafted on the surface of HA nanoparticles and the grafting amount was about 8.9 g of CS on per hundred grams of HA. The grafted chitosan chains can prevent HA nanoparticles from aggregation and greatly enhance the colloidal stability of HA in water. The 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay demonstrats that the cytotoxicity of CS modified HA(HA-CS) is negligible and thus HA-CS may find potential application in biomedical fields.

Key words: Hydroxyapatite, Chitosan, Surface modification, Nanocomposite, Biomaterial

WEI Junchao, GUO-WANG Peiyao, CUI Liguo, ZHANG Haobin, DAI Yanfeng, LIU Tianxi. Novel Method to Graft Chitosan on the Surface of Hydroxyapatite Nanoparticles via “Click” Reaction[J]. Chemical Research in Chinese Universities, 2014, 30(6): 1063-1065.

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Novel Method to Graft Chitosan on the Surface of Hydroxyapatite Nanoparticles via “Click” Reaction

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