Synthesis and Characterization of Novel N-Phenylacetamide Bearing 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents

doi:10.1007/s40242-017-6327-3

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (1): 70-73.doi: 10.1007/s40242-017-6327-3

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Synthesis and Characterization of Novel N-Phenylacetamide Bearing 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents

LI Bochao¹, LIN Xinrui², ZHANG Yumin³, ZHANG Dawei³, XIAO Yang¹, LIN Feng¹

1. School of Life Sciences, Jilin University, Changchun 130012, P. R. China;
2. School of Nursing, Northeast Normal University, Changchun 130117, P. R. China;
3. School of Chemistry, Jilin University, Changchun 130012, P. R. China

Received:2016-07-28 Revised:2016-09-18 Online:2017-02-01 Published:2016-11-14
Contact: LIN Feng,E-mail:linfeng@jlu.edu.cn E-mail:linfeng@jlu.edu.cn
Supported by:
Supported by the Fund for the 12th Five-year Scientific and Technical Research Plan of Department of Education of Jilin Province, China(No.2014B002).

Abstract

Abstract:

A new series of 1-substituted phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone derivatives 3a-3f was synthesized and their structures were characterized by IR, ¹H NMR, ¹³C NMR and HRMS spectral analysis. Antimicrobial activities of the derivatives were measured against both bacteria and fungi. In vitro antifungal evaluation showed that five compounds(3b-3f) had growth inhibitory effects on the tested fungus, and three of them(3b, 3c and 3e) showed special efficacy against Gram negative bacteria.

Key words: N-Phenylacetamide, 1,2,4-Triazole, Antibacterial activity, Antifungal activity

LI Bochao, LIN Xinrui, ZHANG Yumin, ZHANG Dawei, XIAO Yang, LIN Feng. Synthesis and Characterization of Novel N-Phenylacetamide Bearing 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents[J]. Chemical Research in Chinese Universities, 2017, 33(1): 70-73.

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Synthesis and Characterization of Novel N-Phenylacetamide Bearing 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents

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