Light-stimulus Dual-drug Responsive Nanoparticles for Photoactivated Therapy Using Mesoporous Silica Nanospheres

doi:10.1007/s40242-018-8077-2

Abstract

Abstract: Photoactivated therapy is an exciting new method of cancer treatment. A new light-stimulus dual-drug responsive nanoparticles based on mesoporous silica nanoparticles(MSN) were developed to control cellular anticancer drug release. The prepared Curcumin(Cur)-loaded nanoparticles MSN-Pt-PEG@Cur[PEG=poly(ethylene glycol)] could be activated by photostimulation to generate reactive oxygen species(ROS) from Cur and Pt(Ⅱ) from Pt(IV), respectively. Compared with free anti-cancer drugs' chemotherapy and single photoactivated therapy, the prepared MSN-Pt-PEG@Cur displayed increased cytotoxicity. Therefore, the strategy of light-stimulus dual-drug responsive nanoparticles is a promising approach to photoactivated therapy.

Key words: Photoactivated therapy, Dual-drug nanoparticle, Curcumin, Platinum

WU Peng, ZHOU Dongfang, HUANG Yubin, LI Jizhen. Light-stimulus Dual-drug Responsive Nanoparticles for Photoactivated Therapy Using Mesoporous Silica Nanospheres[J]. Chemical Research in Chinese Universities, 2018, 34(4): 676-683.

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