Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles

doi:10.1007/s40242-020-9029-1

Abstract

Abstract: Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues. To promote the antibacterial and sealing effects of a root canal filling, core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer, zinc oxide-eugenol(ZOE). The obtained CaO/ZnO particles had a size of 80-90 nm and a core-shell structure. The film thickness, flow rate, pH, and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested. The pH and calcium ion release results showed a slight increase in the prepared nanospheres, with a flow rate of 24.22 mm and a formed film thickness of 30 μm, which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials). Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05). A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nano-spheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05). The core-shell structured CaO/ZnO nanosphere paste displayed excellent sealing and antibacterial properties, and it has promising application potential in endodontics.

Key words: CaO, ZnO, Antibacterial activity, Core-shell structured nanosphere, Microleakage

WANG Lili, LIU Yanan, PENG Xiaoxing, SUN Yuanqing, LIU Xiaohua, LIU Huimin, LIN Quan, SUN Hongchen, YANG Bai, LI Xiangwei. Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles[J]. Chemical Research in Chinese Universities, 2020, 36(5): 970-975.

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