Interactions of Phenanthroline Compounds with i-Motif DNA

doi:10.1007/s40242-014-3391-9

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (3): 495-499.doi: 10.1007/s40242-014-3391-9

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Interactions of Phenanthroline Compounds with i-Motif DNA

GAO Ning, WANG Yanbo, WEI Chunying

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, P. R. China

Received:2013-09-16 Revised:2013-11-18 Online:2014-06-01 Published:2013-11-25
Contact: WEI Chunying E-mail:weichuny@sxu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21041008, 21171108), the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20101401110009), and the Research Project of Shanxi Scholarship Council of China(No.2011-016).

Abstract

Abstract:

The interactions of each of three phenanthroline derivatives 1, 2 and 3 with the human telomeric i-motif DNA were investigated. The results suggest these compounds are potent binders. The compounds could stabilize the structure of i-motif DNA by π-π stacking. Moreover, the binding constants of the compounds with i-motif DNA were (2.71―8.12)×10⁴ L·mol^-¹, and the binding stoichiometry ratio was 1:1. CD studies reveal that the binding by phenanthroline compounds perturbs the conformation of i-motif DNA.

Key words: i-Motif DNA, Phenanthroline derivative, Interaction

GAO Ning, WANG Yanbo, WEI Chunying. Interactions of Phenanthroline Compounds with i-Motif DNA[J]. Chemical Research in Chinese Universities, 2014, 30(3): 495-499.

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