Nanocomposites Facilitate the Removal of Aβ Fibrils for Neuroprotection

doi:10.1007/s40242-021-1372-3

Abstract

Abstract: Accumulation of β-amyloid(Aβ) fibrils in the brain is one of the main culprits in Alzheimer’s disease(AD) progression, which initiates the neuronal damage and subsequent neurodegeneration. Various anti-Aβ agents have shown the potentials to dissociate Aβ fibrils. However, these approaches can’t facilitate the removal of Aβ fibrils, resulting in a disappointing therapeutic effect. Herein, we demonstrate an integrated polymer nanocomposite(NP-GLVFF-IgG) that can dissociate Aβ fibrils into fragments and activate microglia to remove the fragments via Fc receptors-mediated phagocytosis. NP-GLVFF-IgG is constructed by an albumin/polymer hybrid nanoparticle with Gly-Leu-Val-Phe-Phe (GLVFF) peptides and Immunoglobulin G(IgG) molecules on the surface. In this design, NP-GLVFF-IgG achieves to dissociate the Aβ fibrils by the strong hydrogen-bonding interactions between Aβ fibrils and GLVFF peptides. Then, NP-GLVFF-IgG activates the microglial phagocytosis, thereby achieving an enhanced phagocytic removal of Aβ fibrils for neuroprotection. Moreover, NP-GLVFF-IgG achieves to trigger the effective removal of Aβ fibrils even under inflammatory condition that usually suppressed phagocytosis. Therefore, NP-GLVFF-IgG has great potential as a novel therapeutic platform for effective AD therapy.

Key words: Alzheimer’s disease, Aβ fibril, Nanocomposite, Hydrogen-bonding interaction, Microglia

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CHAI Jingshan, LI Qiushi, ZHAO Yu, LIU Yang. Nanocomposites Facilitate the Removal of Aβ Fibrils for Neuroprotection[J]. Chemical Research in Chinese Universities, 2022, 38(2): 522-528.

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URL: https://crcu.jlu.edu.cn/EN/10.1007/s40242-021-1372-3

https://crcu.jlu.edu.cn/EN/Y2022/V38/I2/522

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[1]	GAO Huimin, SHI Rui, ZHU Youliang, QIAN Hujun and LU Zhongyuan. Coarse-grained Dynamics Simulation in Polymer Systems: from Structures to Material Properties [J]. Chemical Research in Chinese Universities, 2022, 38(3): 653-670.
[2]	Hakan, AHAL, Gülben TORĞUT, Erdal CANPOLAT. Optimization of Electrical Conductivity of SA-graphene Nanocomposites Using Response Surface Methodology [J]. Chemical Research in Chinese Universities, 2022, 38(2): 596-602.
[3]	LAN Weifei, HU Ruifeng, HUANG Danrong, DONG Xu, SHEN Gangyi, CHANG Shan, DAI Dongsheng. Palladium Nanoparticles/Graphdiyne Oxide Nanocomposite with Excellent Peroxidase-like Activity and Its Application for Glutathione Detection [J]. Chemical Research in Chinese Universities, 2022, 38(2): 529-534.
[4]	PAN Chuanqi, LIU Xiaoxuan, ZHANG Xiang, MAO Feihong, XU Peiyan, ZHU Yuhua, DENG Hongtao, LUO Zhu, SUN Hongwei, ZHANG Lizhi, GUO Yanbing. Fabrication and Excellent Antibacterial Activity of Well-defined CuO/Graphdiyne Nanostructure [J]. Chemical Research in Chinese Universities, 2021, 37(6): 1341-1347.
[5]	XIANG Siyuan, MENG Qingnan, ZHANG Kai, GU Yue, LIU Wendong, YANG Bai. Facile Synthesis of ZnO-Au Nanopetals and Their Application for Biomolecule Determinations [J]. Chemical Research in Chinese Universities, 2019, 35(5): 924-928.
[6]	WU Shuo, YANG Xinlan, ZHAO Yanqiu. Ru(II) Bipyridyl Complex and TiO₂ Nanocomposite Based Biomolecule-free Photoelectrochemical Sensor for Highly Selective Determination of Ultra-trace Hg²⁺ in Aqueous Systems [J]. Chemical Research in Chinese Universities, 2019, 35(3): 370-376.
[7]	GUAN Renquan, ZHAI Hongju, SUN Dewu, ZHANG Junkai, WANG Yan, LI Jiaxin. Effects of Ag Doping Content and Dispersion on the Photocatalytic and Antibacterial Properties in ZnO Nanoparticles [J]. Chemical Research in Chinese Universities, 2019, 35(2): 271-276.
[8]	HAN Donglai, LI Boxun, XING Guoliang, ZHANG Yuanyuan, CHEN Yue, SUN Yantao, ZHANG Yongjun, LIU Yang, YANG Jinghai. Facile Synthesis of Fe₃Pt-Ag Nanocomposites for Catalytic Reduction of Methyl Orange [J]. Chemical Research in Chinese Universities, 2018, 34(6): 871-876.
[9]	ZHANG Jindi, WANG Jun, ZHAO Lina, YANG Wenlong, BI Meng, WANG Yuchang, NIU Hongyan, LI Yuxin, WANG Binsong, GAO Yachen, LI Chensha, HUANG Xuezhen. Photo Responsive Silver Nanoparticles Incorporated Liquid Crystalline Elastomer Nanocomposites Based on Surface Plasmon Resonance [J]. Chemical Research in Chinese Universities, 2017, 33(5): 839-846.
[10]	LI Xiaoshuang, LIU Yuan, GUO Chaofeng, LIU Haiyang, WANG Gang, CAI Qiang, YAO Youwei. Influence of Layered Aluminoborophosphate on Flame Retardance, Crystallization Behaviors and Mechanical Properties of Polyamide 66 Systems [J]. Chemical Research in Chinese Universities, 2016, 32(1): 127-133.
[11]	CAO Wei, MA Yiran, ZHOU Wei, GUO Lin. One-pot Hydrothermal Synthesis of rGO-Fe₃O₄ Hybrid Nanocomposite for Removal of Pb(II) via Magnetic Separation [J]. Chemical Research in Chinese Universities, 2015, 31(4): 508-513.
[12]	WEI Junchao, GUO-WANG Peiyao, CUI Liguo, ZHANG Haobin, DAI Yanfeng, LIU Tianxi. Novel Method to Graft Chitosan on the Surface of Hydroxyapatite Nanoparticles via “Click” Reaction [J]. Chemical Research in Chinese Universities, 2014, 30(6): 1063-1065.
[13]	LÜ Leilei, CHEN Zhimin, XU Guiheng, ZHANG Jianan, XU Qun. Pine Needle-like Nanocomposite：Supercritical CO₂ Assisted Polythiophene Synthesis on Carbon Nanotubes [J]. Chemical Research in Chinese Universities, 2014, 30(3): 521-526.
[14]	ZHANG Yinan, JIANG Dong, HE Zhi, YU Yunwu, ZHANG Haibo, JIANG Zhenhua. Hydrothermal Synthesis of PEG-capped ZnS：Mn²⁺ Quantum Dots Nanocomposites [J]. Chemical Research in Chinese Universities, 2014, 30(1): 176-180.
[15]	LUO Pei-wen, YU Jian-guo, SHI Zhi-qiang, HUANG Hua, LIU Lang, ZHAO Yong-nan, LI Guo-dong, ZOU Yong-cun. Preparation and Supercapacitive Properties of Fe₂O₃/Active Carbon Nanocomposites [J]. Chemical Research in Chinese Universities, 2012, 28(5): 780-783 .

Nanocomposites Facilitate the Removal of Aβ Fibrils for Neuroprotection

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