Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (1): 137-143.doi: 10.1007/s40242-014-3284-y

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Synthesis and Release Behavior of a Hybrid of Camptothecin Intercalated Dodecyl Sulfate Modified Layered Double Hydroxide

LI Yan1, DU Na1, HOU Wanguo1,2, LIU Shaojie2   

  1. 1. Key Laboratory of Colloid & Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, P. R. China;
    2. National Engineering Research Center for Colloidal Materials, Shandong University, Jinan 250100, P. R. China
  • Received:2013-07-08 Revised:2013-10-16 Online:2014-02-01 Published:2013-11-25
  • Contact: LIU Shaojie,E-mail:shaojieliu@sdu.edu.cn E-mail:shaojieliu@sdu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.21173135) and the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20110131130008).

Abstract:

The intercalation of a non-ionic and poorly water-soluble drug, camptothecin(CPT), into dodecyl sulfate (DS) modified layered double hydroxide(LDH) was carried out via a secondary intercalation method to obtain a CPT-DS-LDH hybrid. The in vitro CPT release eFxaminations from the hybrid show that the hybrid can well control the release of CPT, which indicates that the hybrid is a potential drug controlled-release system. Moreover, the intercalation kinetics of CPT into the DS modified LDH fits for the pseudo-second-order model. And the release kinetic process of CPT from the CPT-DS-LDH hybrid at pH=4.8 can be described with pseudo-first-order model, while that at pH=7.2 can be described with both pseudo-first-order model and pseudo-second-order model. Meanwhile, the release mechanism of CPT from the CPT-DS-LDH hybrid was discussed.

Key words: Layered double hydroxide(LDH), Camptothecin, Hybrid, Controlled release