Effects of the Molecular Weight of PLGA on Degradation and Drug Release In vitro from an mPEG-PLGA Nanocarrier

doi:10.1007/s40242-016-6155-x

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (5): 848-853.doi: 10.1007/s40242-016-6155-x

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Effects of the Molecular Weight of PLGA on Degradation and Drug Release In vitro from an mPEG-PLGA Nanocarrier

LIU Rui², WANG Yan¹, MA Yudan^1,4, WU Yi³, GUO Yi¹, XU Li¹

1. Key laboratory for Molecular Enzymology and Engineering, Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, P. R. China;
2. Department of Endocrinology, China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China;
3. College of Pharmacy, Jilin University, Changchun 130021, P. R. China;
4. Jilin Research Institute of Sports Science, Changchun 130022, P. R. China

Received:2016-04-22 Revised:2016-08-12 Online:2016-10-01 Published:2016-08-15
Contact: GUO Yi, WU Yi E-mail:guoyi@jlu.edu.cn;wuyi@jlu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.81271697, 81571791, 31571017).

Abstract

Abstract:

We successfully synthesized four kinds of copolymers with varying molecular weights of poly(lactide-co-glycolide)(PLGA) to yield methoxy-poly(ethylene glycol)-block-poly(lactide-co-glycolide)(mPEG-PLGA) nanocarriers:mPEG-PLGA(3k), mPEG-PLGA(9k), mPEG-PLGA(11k) and mPEG-PLGA(16k). An antitumor drug, 10-hydroxycamptothecin(HCPT), was encapsulated into the mPEG-PLGA nanocarrier cores by self-assembly in dialysis. The lower molecular weight nanocarriers degraded more quickly, resulting in mass loss, pH decline, and a rapid HCPT release rate in vitro. The degradation and drug release of the nanocarriers were dependent on the PLGA molecular weight. However, the larger molecular weight nanocarriers could not increase the loading content and encapsulation efficiency. Considering the antitumor effect of these nanocarriers, the mPEG-PLGA(9k) nanocarrier, which had the highest drug loading content[(7.72±0.57)%] and a relatively high encapsulation efficiency[(22.71±5.53)%], is an optimum agent for drug delivery.

Key words: Poly(lactide-co-glycolide), 10-Hydroxycamptothecin, Nanocarrier, Drug delivery

LIU Rui, WANG Yan, MA Yudan, WU Yi, GUO Yi, XU Li. Effects of the Molecular Weight of PLGA on Degradation and Drug Release In vitro from an mPEG-PLGA Nanocarrier[J]. Chemical Research in Chinese Universities, 2016, 32(5): 848-853.

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Effects of the Molecular Weight of PLGA on Degradation and Drug Release In vitro from an mPEG-PLGA Nanocarrier

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