Synthesis and Anti-VSMC Vegetation Activities of New Aurone Derivatives

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (3): 438-442.

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Synthesis and Anti-VSMC Vegetation Activities of New Aurone Derivatives

FAN Rui^1,2, BAN Shu-rong¹, FENG Xiu-e¹, ZHAO Chen-xiao¹, LI Qing-shan¹

1. School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, P. R. China;
2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China

Received:2011-06-03 Revised:2011-07-23 Online:2012-05-25 Published:2012-05-03
Contact: LI Qing-shan E-mail:qingshanl@yahoo.com
Supported by:
Supported by the National Natural Science Foundation of China(No.81172938), the Program for the Top Science and Technology Innovation Teams of Higher Learning Institutions of Shanxi Province, China, the Shanxi Foundation for Overseas Returned, China(No.2008-51) and the Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi Province, China.

Abstract

Abstract: A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells(VSMC) vegetation activities were evaluated by the 3-(4,5-dimethylthlazol-2-yl)-2,5- diphenyltetrazolium bromide(MTT) method with tetrandrine as a positive contrast drug. The structures of the compounds were confirmed by ¹H NMR, ¹³C NMR and electrospray ionization mass spectrometry(ESI-MS). Several new compounds exhibited promising activity against VSMC proliferation and the preliminary structure-activity relationships( SAR) were discussed in order to investigate the essential structures required for their bioactivities.

Key words: Aurone derivative, Anti-vascular smooth muscle cell(VSMC) vegetation activity, Synthesis

FAN Rui, BAN Shu-rong, FENG Xiu-e, ZHAO Chen-xiao, LI Qing-shan. Synthesis and Anti-VSMC Vegetation Activities of New Aurone Derivatives[J]. Chemical Research in Chinese Universities, 2012, 28(3): 438-442.

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Synthesis and Anti-VSMC Vegetation Activities of New Aurone Derivatives

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