Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (1): 166-170.

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Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

JI Jin-gou*, ZHANG Jing-fen, HAO Shi-lei, WU Dan-jun, LIU Li, XU Yi

College of Chemistry and Chemical Engineering, University of Chongqing, Chongqing 400030, P. R. China

Received:2011-01-13 Revised:2011-07-08 Online:2012-01-25 Published:2011-12-27
Contact: Jin-gou E-mail:jingou_ji@yahoo.com.cn
Supported by:
Supported by the Key Scientific and Technological Projects of Chongqing Science and Technology Commission, China (No.CSTC2010AC5050) and the Chongqing University(China) Postgraduates' Science and Innovation Fund (No.CDJXS10220008).

Abstract

Abstract: Chitosan/cyclodextrin/trisodium citrate(CS/CD/TSC) nanoparticles with ibuprofen(IBU) loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were investigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of +30.72 mV. The in vitro release studies show that the controlled release of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.

Key words: Chitosan, Cyclodextrin, Nanoparticle, Ibuprofen(IBU)

JI Jin-gou, ZHANG Jing-fen, HAO Shi-lei, WU Dan-jun, LIU Li, XU Yi. Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study[J]. Chemical Research in Chinese Universities, 2012, 28(1): 166-170.

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Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

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