Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (4): 840-845.doi: 10.1007/s40242-021-1196-1

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Advanced Nanomaterials for Multimodal Molecular Imaging

YUAN Hui1, LIANG Hanyu2, HOU Peidong1,2, LI Juan1,2   

  1. 1. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou 310022, P. R. China;
    2. Key Laboratory for Analytical Science of Food Safety and Biology of Ministry of Education, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350002, P. R. China
  • Received:2021-04-30 Revised:2021-07-06 Online:2021-08-01 Published:2021-07-27
  • Contact: LI Juan E-mail:juanli@sjtu.edu.cn
  • Supported by:
    This work was supported by the National Key Research and Development Program of China(No.2020YFA0909000), the National Natural Science Foundation of China(No.91959102), the Shanghai Rising-Star Program, China(No. 19QA1405400) and the Postdoctoral Science Foundation of Zhejiang Province, China(No.ZJ2020131).

Abstract: The development of multimodal molecular imaging contrast agents based on versatile nanomaterials has recently attracted much attention in disease diagnosis and therapeutic delivery. Contrast agents made from nanoparticles and used for multimodal imaging in vivo provide a multidimensional pathophysiological overview of diseases. This review summarizes recently developed advanced nanomaterials for multimodal molecular imaging. We comprehensively discuss these nanoparticle contrast agents in terms of their targeting modalities, limitations in clinical translation and future directions.

Key words: Molecular imaging, Nanoparticle contrast agent, Multimodal imaging, In vivo imaging, Biomedicine