Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (5): 777-779.

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Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity

WU Jian-feng^1*, TU Peng-fei², ZHAN Hai-tao¹ and GAO Jing-chun³

1. College of Medicine, Foshan University, Foshan 528000, P. R. China;
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China;
3. Department of Biology and Chemistry, City University of Hongkong, Hong Kong SPR, P. R. China

Received:2011-04-02 Revised:2011-05-24 Online:2011-09-25 Published:2011-09-06
Contact: WU Jian-feng E-mail:jianfeng839@sina.com
Supported by:
Supported by the Natural Science Foundation of Guangdong Province, China(No.9151064201000042).

Abstract

Abstract: Two new dioxyxanthones, polyhongkongenoxanthones A and B(1 and 2) were isolated from the herbs of Polygala hongkongensis, together with six known xanthones. Their structures were elucidated on the basis of chemical and spectroscopic evidence. The isolates were tested for their cytotoxicity against three tumor cell lines(HepG2, GLC-82 and MCF-7, HepG2=human hepatocellular carcinoma cells; GLC-82=human lung carcinoma cells; MCF-7= human breast carcinoma cells) by MTT assay, among which polyhongkongenoxanthone B(2), 1,7-dihydroxy-2,3- methylenedioxyxanthone(3) and 1,7-dihydroxy-3,4,8-trimethoxyxanthone(6) are potential antitumor candidate due to their significant cytotoxic effects on the three cell lines..

Key words: Polygala hongkongensis, Polygalaceae, Dioxyxanthone, Polyhongkongenoxanthone A and B, Cytotoxicity

WU Jian-feng*, TU Peng-fei, ZHAN Hai-tao and GAO Jing-chun. Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity[J]. Chemical Research in Chinese Universities, 2011, 27(5): 777-779.

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Dioxyxanthones from Polygala hongkongensis and Their Cytotoxicity

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