Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline

doi:10.1007/s40242-014-4240-6

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (6): 937-940.doi: 10.1007/s40242-014-4240-6

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Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline

LIU Yazhou^1,2, HUANG Lan¹, SUN Qianyun¹, ZHANG Maosheng¹, LI Tianlei¹, LIANG Guangyi¹, PAN Weidong¹

1. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, P. R. China;
2. School of Pharmaceutical Sciences, Guizhou University, Guiyang 55000, P. R. China

Received:2014-06-27 Revised:2014-09-04 Online:2014-12-01 Published:2014-09-15
Contact: LIANG Guangyi, PAN Weidong E-mail:guangyi_liang@126.com;wdpan@163.com
Supported by:
Supported by the National Natural Science Foundation of China(No.81360479), the Ministry of Science and Technology of China(No.2012CB722601) and the Science and Technology Department of Guizhou Province, China(Nos.QKHZYZ[2011]5085, QKHRZ[2011]33).

Abstract

Abstract:

A series of derivatives of tetrandrine and fangchinoline was designed and synthesized to find more active anti-cancer compounds. Their anti-cancer activities were tested against human hepatocellular carcinoma BEL-7402 and PLC/PRF/5 cells, human lung adenocarcinoma A549 cells as well as human leukaemia K562 cells, and the structure-activity relationship(SAR) was also studied. All the compounds except B1 exhibited superior inhibitory activities against PLC/PRF/5 cells with half maximal inhibitory concentration(IC₅₀) values of less than 15 μmol/L, and compounds A2, A4, B2 and B4 showed IC₅₀ values of less than 9 μmol/L. Compounds A2, A6, B2 and B4 showed potent anti-cancer activities against all the tested cells with IC₅₀ values of less than 10 μmol/L. The results show that terandrine and fangchinoline derivatives are potential suppressors to human cancer.

Key words: Tetrandrine, Fangchinoline, Derivative, Cytotoxicity

LIU Yazhou, HUANG Lan, SUN Qianyun, ZHANG Maosheng, LI Tianlei, LIANG Guangyi, PAN Weidong. Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline[J]. Chemical Research in Chinese Universities, 2014, 30(6): 937-940.

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Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline

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