Structure and Activity of a New Sapogenin from Chlorophytum laxum R. Br.

doi:10.1007/s40242-018-8114-1

Chemical Research in Chinese Universities ›› 2018, Vol. 34 ›› Issue (5): 732-735.doi: 10.1007/s40242-018-8114-1

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Structure and Activity of a New Sapogenin from Chlorophytum laxum R. Br.

CHU Chenliang, CUI Ting, LI Sida, ZHAN Ruoting, GAO Youheng

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China

Received:2018-04-09 Revised:2018-06-02 Online:2018-10-01 Published:2018-06-19
Contact: GAO Youheng,Email:gaoyouheng@gzhtcm.edu.cn E-mail:gaoyouheng@gzhtcm.edu.cn
Supported by:
Supported by the Fund of the Graduate School of Guangzhou University of Chinese Medicine, China(No.20142105101).

Abstract

Abstract: A new steroidal sapogenin named 25-R-spirosta-3,5-dien-12β-ol(1) was isolated from the dried roots of Chlorophytum laxum R. Br. along with five known compounds, namely, diosgenin(2), stigmasterol(3), β-sitosterols(4), estigmasterol-3-O-β-D-glicopyranoside(5) and 3-O-β-authemisol(6). The structure of compound 1 was elucidated by the analysis of IR, HRESI-MS, 1D and 2D NMR spectral data. Compounds 2-5 were isolated from Chlorophytum laxum R. Br. In addition, all the compounds were evaluated for cytotoxicity on the human nasopharyngeal carcinoma cancer cell line 5-8F. Among them, the newly identified 25-R-spirosta-3,5-dien-12β-ol(1) and diosgenin(2) exhibited high cytotoxicity on 5-8F cells, with IC₅₀ values of 24.8 and 41.9 μmol/L, respectively.

Key words: Chlorophytum laxum R.Br., Steroidal sapogenin, Cytotoxicity

CHU Chenliang, CUI Ting, LI Sida, ZHAN Ruoting, GAO Youheng. Structure and Activity of a New Sapogenin from Chlorophytum laxum R. Br.[J]. Chemical Research in Chinese Universities, 2018, 34(5): 732-735.

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Structure and Activity of a New Sapogenin from Chlorophytum laxum R. Br.

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