利用各种肝质粒还原代谢芳香硝基化合物

Abstract

Abstract: Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Toward the 4-nitro-1,2-dicyanbenzen substrate 1a, the pig, rat and sheep livers exhibited the higher reactivity, and the cyprinoid was inefficient for the reduction. Contrasted to 1a, it was difficult to reduce the monocyannitrobenzene 2a by pig liver. Compared with the baker’s yeast and grape cells, the liver microsomes exhibited higher reactivity toward the hydroxylamines.

Key words: Liver microsomes, Reduction, Nitroaromatic compounds, Aromatic hydroxylamines

[1]	XU Guangyuan, LIU Qin, YAN Huan. Recent Advances of Single-atom Catalysts for Electro-catalysis [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1146-1150.
[2]	BU Ran, LU Yingying, ZHANG Bing. Covalent Organic Frameworks Based Single-site Electrocatalysts for Oxygen Reduction Reaction [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1151-1162.
[3]	MIAO Tianchang, DI Xin, HAO Feini, ZHENG Gengfeng, HAN Qing. Polymeric Carbon Nitride-based Single Atom Photocatalysts for CO₂ Reduction to C₁ Products [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1197-1206.
[4]	MA Chunrong, SONG Bingyi, MA Zhentao, WANG Xiaoqian, TIAN Lin, ZHANG Haoran, CHEN Cai, ZHENG Xusheng, YANG Li-ming, WU Yuen. A Supported Palladium on Gallium-based Liquid Metal Catalyst for Enhanced Oxygen Reduction Reaction [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1219-1225.
[5]	QIAN Shengjie, WANG Yanggang, LI Jun. Single Iron-dimer Catalysts on MoS₂ Nanosheet for Potential Nitrogen Activation [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1226-1231.
[6]	SHU Chengyong, GAN Zhuofan, ZHOU Jia, WANG Zhen, TANG Wei. Highly Efficient Oxygen Reduction Reaction Fe-N-C Cathode in Long-durable Direct Glycol Fuel Cells [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1268-1274.
[7]	ZHENG Meng, WANG Jin. Regulating the Oxygen Affinity of Single Atom Catalysts by Dual-atom Design for Enhanced Oxygen Reduction Reaction Activity [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1275-1281.
[8]	GONG Yu, PAN Jing, ZHANG Lingling, WANG Xiao, SONG Shuyan, ZHANG Hongjie. Metal-Organic Frameworks-derived Indium Clusters/Carbon Nanocomposites for Efficient CO₂ Electroreduction [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1287-1291.
[9]	ZHENG Ruonan, ZHAI Zihui, QIU Chenxi, GAO Rui, LV Yang, SONG Yujiang. Highly Active Electrocatalyst Derived from ZIF-8 Decorated with Iron(III) and Cobalt(III) Porphyrin Toward Efficient Oxygen Reduction in Both Alkaline and Acidic Media [J]. Chemical Research in Chinese Universities, 2022, 38(4): 961-967.
[10]	CHEN Yu, CHEN Yongting, LIAO Yuxiang, CHEN Shengli. A Chemical Dealloying Approach for Pt Surface-enriched Pt₃Co Alloy Nanoparticles as Oxygen Reduction Reaction Electrocatalysts [J]. Chemical Research in Chinese Universities, 2022, 38(4): 991-998.
[11]	JI Yuancheng, XU Jiayun, SUN Hongcheng, and LIU Junqiu. Artificial Photosynthesis(AP): from Molecular Catalysts to Heterogeneous Materials [J]. Chemical Research in Chinese Universities, 2022, 38(3): 688-697.
[12]	CHANG Shunkai, LI Cuiyan, LI Hui, ZHU Liangkui, FANG Qianrong. Stable Thiophene-sulfur Covalent Organic Frameworks for Oxygen Reduction Reaction(ORR) [J]. Chemical Research in Chinese Universities, 2022, 38(2): 396-401.
[13]	ZHANG Yin, MA Shengqian. Laser-induced Synthesis of Ultrafine Gold Nanoparticles in Covalent Organic Frameworks [J]. Chemical Research in Chinese Universities, 2022, 38(2): 468-471.
[14]	YU Xiaoming, MA Yunchao, LI Cuiyan, GUAN Xinyu, FANG Qianrong, QIU Shilun. A Nitrogen, Sulfur co-Doped Porphyrin-based Covalent Organic Framework as an Efficient Catalyst for Oxygen Reduction [J]. Chemical Research in Chinese Universities, 2022, 38(1): 167-172.
[15]	YI Jundong, LI Qiuxia, CHI Shaoyi, HUANG Yuanbiao, CAO Rong. Boron-doped Covalent Triazine Framework for Efficient CO₂ Electroreduction [J]. Chemical Research in Chinese Universities, 2022, 38(1): 141-146.

Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments