Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups

Abstract

Abstract: Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic(imidazo[1,2-b] pyridazine/imidazo[2,1-b]thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by ¹H NMR, IR and MS, and their in vitro antibacterial activities against staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid.

Key words: Oxazolidinone analog, Synthesis, Antibacterial activity

ZHAI Xin, ZHAO Yan-fang, WANG Jia, HONG Wei, HUANG Liang, GONG Ping. Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups[J]. Chemical Research in Chinese Universities, 2006, 22(4): 459-464.

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Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups

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