Synthesis, Characterization and Cytotoxicity of Ammine/Methylamine Platinum(Ⅱ) Complexes with Carboxylates

Abstract

Abstract: Seven novel platinum (Ⅱ) complexes [Pt (Ⅱ) (NH₃) (CH₃NH₂) X₂] (Ⅰ-Ⅶ) (X: CH₃COO^- ,CH₂ ClCOO^- , CHCl₂COO^-, C₆H₅-COO^- , p-CH₃O-C₆H₄-COO^- , p-NH₂-C₆ H₄-COO^- , p-NO₂-C₆H₄-COO^-) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis,IR, UV, and 1 H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin ＞Ⅳ＞Ⅴ＞Ⅵ＞Ⅶ＞Ⅰ＞Ⅱ＞Ⅲ. Moreover, the complexes(Ⅰ-Ⅶ) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G₂/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.

Key words: Ammine/methylamine platinum(Ⅱ) complex, Synthesis, Cytotoxicity, Cell cycle, DNA-binding

ZHANG Jin-chao, SHEN Yong, YANG Meng-su. Synthesis, Characterization and Cytotoxicity of Ammine/Methylamine Platinum(Ⅱ) Complexes with Carboxylates[J]. Chemical Research in Chinese Universities, 2006, 22(3): 278-282.

[1]	FAN Kui, SUN Yining, XU Pengcheng, GUO Jian, LI Zhenhua, SHAO Mingfei. Single-atom Catalysts Based on Layered Double Hydroxides [J]. Chemical Research in Chinese Universities, 2022, 38(5): 1185-1196.
[2]	JI Yuancheng, XU Jiayun, SUN Hongcheng, and LIU Junqiu. Artificial Photosynthesis(AP): from Molecular Catalysts to Heterogeneous Materials [J]. Chemical Research in Chinese Universities, 2022, 38(3): 688-697.
[3]	CHEN Juan, WANG Jiajia, CHEN Chongan and YANG Guoyu. Two New Borates Built by Different Types of {B₉} Cluster Units [J]. Chemical Research in Chinese Universities, 2022, 38(3): 744-749.
[4]	Mohammad Javad TAGHIZADEH, Maryam Saleh MOHAMMADNIA, Masoumeh GHALKHANI, Esmail SOHOULI. Improved Method for the Total Synthesis of Azaperone and Investigation of Its Electrochemical Behavior in Aqueous Solution [J]. Chemical Research in Chinese Universities, 2022, 38(2): 546-551.
[5]	SUN Xiao-Shuang, QIN Dan, LI Xu-Yan, YANG Guo-Yu. A New Tubular Borate Built by[B₁₄O₂₄(OH) ₆]^12- Cluster Units [J]. Chemical Research in Chinese Universities, 2022, 38(1): 123-127.
[6]	WANG Zelin, LIU Guihao, SHEN Tianyang, TAN Ling, ZHAO Yufei, SONG Yu-Fei. Remote Synthesis of Layered Double Hydroxide Nanosheets Through the Automatic Chemical Robot [J]. Chemical Research in Chinese Universities, 2022, 38(1): 217-222.
[7]	ZHANG Xiaosi, YANG Miao, TIAN Peng, LIU Zhongmin. Progress in Seed-assisted Synthesis of (Silico) Aluminophosphate Molecular Sieves [J]. Chemical Research in Chinese Universities, 2022, 38(1): 1-8.
[8]	LUAN Huimin, WU Qinming, ZHANG Jian, WANG Yeqing, MENG Xiangju, XIAO Feng-Shou. Sustainable Synthesis of Core-Shell Structured ZSM-5@Silicalite-1 Zeolite [J]. Chemical Research in Chinese Universities, 2022, 38(1): 136-140.
[9]	FANG Yuan, HEYDARI Zahra, LIU Chenghao, ZHANG Nianyue, CUCCIA Louis A., IVASENKO Oleksandr, PEREPICHKA Dmitrii F.. Glaser Coupling of Substituted Anthracene Diynes on a Non-metallic Surface at the Vapor-Solid Interface [J]. Chemical Research in Chinese Universities, 2021, 37(5): 1143-1148.
[10]	ZHAO Lei, YANG Ge, GUO Hailing, WANG Chunzheng, WANG Lijuan, Svetlana MINTOVA. Effect of Sodium Concentration on the Synthesis of Faujasite by Two-step Synthesis Procedure [J]. Chemical Research in Chinese Universities, 2021, 37(5): 1137-1142.
[11]	ZHANG Ling, FU Yihong, DING Yue, MENG Jiao, WANG Zhenchao, WANG Peiyi. Antibacterial Activity of Novel 18β-Glycyrrhetinic Hydrazide or Amide Derivatives [J]. Chemical Research in Chinese Universities, 2021, 37(3): 662-667.
[12]	DONG Xin, CHEN Xi, ZHOU Zhaohui. Efficient Synthesis of p-Hydroxyphenyl Ethanol from Hydrogenation of Methyl p-Hydroxyphenylacetate with CNTs-promoted Cu-Zr Catalyst [J]. Chemical Research in Chinese Universities, 2021, 37(3): 745-750.
[13]	LI Yuan, LI Ruizhe, LI Zhenhua, WEI Weiqin, OUYANG Shuxin, YUAN Hong, ZHANG Tierui. Effect of Support on Catalytic Performance of Photothermal Fischer-Tropsch Synthesis to Produce Lower Olefins over Fe₅C₂-based Catalysts [J]. Chemical Research in Chinese Universities, 2020, 36(6): 1006-1012.
[14]	PENG Xiaoyu, ZHAO Anran, HUANG Kelin, HU Tingju, LIU Buming, HUANG Yan, CHEN Hailan, CHAI Ling, LIN Cuiwu. Synthesis of Caffeic Acid Sulphonamide Derivatives and Preliminary Exploration of Their Biological Applications [J]. Chemical Research in Chinese Universities, 2020, 36(5): 795-803.
[15]	ZHANG Baochang, LI Yulei, SHI Weiwei, WANG Tongyue, ZHANG Feng, LIU Lei. Chemical Synthesis of Proteins Containing 300 Amino Acids [J]. Chemical Research in Chinese Universities, 2020, 36(5): 733-747.

Synthesis, Characterization and Cytotoxicity of Ammine/Methylamine Platinum(Ⅱ) Complexes with Carboxylates

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments