Chemical Research in Chinese Universities ›› 2005, Vol. 21 ›› Issue (4): 447-451.

• Articles • Previous Articles     Next Articles

Syntheses of Nucleoside Derivatives Containing Fmoc- or Trityl-protected Amino Acids

GUO Hui, ZOU Wu-xin, JI Qi, MA Yu-xin, MENG Ji-ben   

  1. Department of Chemistry, Nankai University, Tianjin 300071, P. R. China
  • Received:2004-09-24 Online:2005-07-24 Published:2011-08-06
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.20072018 and 20372039).

Abstract: Facile direct esterification reactions between 2′,3′-O-isopropylidene-nucleosides and Fmoc- or trityl-protected amino acids via N,N-dicyclohexyl-carbodiimide(DCC) mediated condensation are described. These reactions offer a mild and convenient method to synthesize aminoacylated nucleoside derivatives.

Key words: Nucleoside, Amino acid, Esterification,2′,3′-O-Isopropylidene-nucleoside