Aerobic Alcohol Ammoxidation Catalyzed by Copper(I)/Amino Acid: a Scalable Protocol to Nitriles

doi:10.1007/s40242-016-6067-9

Abstract

Abstract:

A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles was developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide(CuI) as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates, even the substrates bearing oxidation- sensitive groups such as MeS-, alkenyl and -NH₂ can also work well. In addition, the protocol is readily scaled up to more than 20 g and the product can be obtained just through filtration or distillation without conventional column chromatography.

Key words: Alcohol, Amino acid, Nitrile, Copper iodide, Scale up

ZHANG Guofu, ZHANG Guihua, LEI Jie, LI Shasha, XU Shengjun, DING Chengrong, SHAN Shang. Aerobic Alcohol Ammoxidation Catalyzed by Copper(I)/Amino Acid: a Scalable Protocol to Nitriles[J]. Chemical Research in Chinese Universities, 2016, 32(4): 586-593.

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