Synthesis and Antibacterial Activities of Erythromycin Derivatives

Abstract

Abstract: Ten new erythromycin antibacterial agents containing amidino group were designed and synthesized from erythromycin via oximation, reduction and condensation.Their structures were confirmed by MS and ¹³C NMR; the synthetic condition(reaction medium)was explored; and their in vtiro antibacterial activities were tested.Compound HMA-3 showed antibacterial activity against staphylococcus aureus, which is equivalent to that of erythromycin A.Compounds HMA-8 and HMA-4 also showed an antibacterial activitiy.But no compound showed bactericidal activity.

Key words: Erythromycin derivatives, Synthesis, Antibacterial activities

FENG Run-liang, GONG Ping, FANG Lin, HONG Wei. Synthesis and Antibacterial Activities of Erythromycin Derivatives[J]. Chemical Research in Chinese Universities, 2005, 21(2): 177-182.

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Synthesis and Antibacterial Activities of Erythromycin Derivatives

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